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Vinorelbine

Vinorelbine Struktur
71486-22-1
CAS-Nr.
71486-22-1
Englisch Name:
Vinorelbine
Synonyma:
CL069;CS-404;F 80520;NSC32797;NSC 32797;NSC-32797;NVBKW-2307;VINORELBINE;Navelbine(R);KW 2307 base
CBNumber:
CB3469220
Summenformel:
C45H54N4O8
Molgewicht:
778.93
MOL-Datei:
71486-22-1.mol

Vinorelbine Eigenschaften

alpha 
D20 +52.4° (c = 0.3 in CHCl3)
Dichte
1.36±0.1 g/cm3(Predicted)
storage temp. 
Store at 4°C, protect from light
L?slichkeit
>25.9mg/mL in DMSO
Aggregatzustand
Powder
pka
11.36±0.60(Predicted)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2939799090
Giftige Stoffe Daten 71486-22-1(Hazardous Substances Data)
Toxizit?t LD50 in mice (mg/m2): 72 i.v.; 78 orally (Mathé, Reizenstein)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H341 Kann vermutlich genetische Defekte verursachen. Keimzellmutagenit?t Kategorie 2 Warnung P201,P202, P281, P308+P313, P405,P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Vinorelbine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vinorelbine is a semisynthetic vinca alkaloid differing from vinblastine in the catharantine moiety of the molecule. It is claimed to have a broad spectrum of action both in vifro and in vivo; clinically it has been found effective in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and Hodgkins disease.

Verwenden

Vinorelbine base is an antineoplastic agent with anti-mitotic properties.

Definition

ChEBI: A vinca alkaloid with a norvinblastine skeleton.

Pharmakokinetik

This semisynthetic alkaloid is unique in having oral bioavailability, but it currently is available only for IV injection. The initial phase elimination half-life is on par with that observed for vincristine and vinblastine, and the terminal phase half-life is between 28 and 44 hours.

Clinical Use

Vinorelbine is particularly useful in the treatment of advanced non–small cell lung cancer and can be administered alone or in combination with cisplatin. It is thought to interfere with mitosis in dividing cells through a relatively specific action on mitotic microtubules.

Nebenwirkungen

Although dose-limiting granulocytopenia is the major adverse effect, potentially fatal interstitial pulmonary changes have been noted, and patients with symptoms of respiratory distress should be promptly evaluated. As with all vinca alkaloids, elimination is primarily hepatobiliary, and dosage reduction should be considered in patients with liver dysfunction.

Vinorelbine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Vinorelbine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 217)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Echemi Group
86-18905328650 18905328650
pharma@echemi.com CHINA 215 58

71486-22-1()Verwandte Suche:


  • ANX-530, KW-2307, 5'-Noranhydrovinblastine
  • nor-5’-anhydrovinblastine
  • VINORELBINE
  • (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(Methoxycarbonyl)-2,6-Methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-Methoxy-1-Methyl-aspidosperMidine-3-ca
  • 5-Noranhydrovinblastine
  • 3’,4'-Didehydro-4ideoxy-C’-norvincaleukoblastine
  • NVBKW-2307
  • 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine
  • Vinorelbine(Navelbine)
  • Navelbine(R)
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl- , methyl ester, (2b,3b,4b,5a,12R,19a)-
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12b,19a)-
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12R,19a)- (9CI)
  • C'-Norvincaleukoblastine, 3',4'-didehydro-4'-deoxy-
  • F 80520
  • KW 2307 base
  • Navelbine base
  • 3’,4’-didehydro-4’-deoxy-c’-norvincaleukoblastin
  • vinorelbine D-tartrate
  • AspidosperMidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8
  • CS-404
  • Vinblastine Impurity K
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
  • Vinorelbine USP/EP/BP
  • Vinorelbine (KW-2307)
  • NSC 32797
  • NSC32797
  • NSC-32797
  • CL069
  • Vinorelbine, 98%, from Catharanthus roseus (L.) G. Don
  • vinorelbine ditartrate ,navelbine,nvb
  • Methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((2R,6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate
  • Vinorelbine EP Impurity C (2R,8S-Isomer)
  • 71486-22-1
  • C45H54N4O8
  • ZOMIG
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • Active Pharmaceutical Ingredients
  • Antineoplastic
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