5-Aziridino-2,4-dinitrobenzamide
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- CAS-Nr.
- 21919-05-1
- Englisch Name:
- 5-Aziridino-2,4-dinitrobenzamide
- Synonyma:
- CB-954;CB-1954;tretazicar;NSC 115829;CB 1954;CB-1954;Tretazicar (>Tretazicar (>94%);CB1954(TRETAZICAR);Tretazicar (CB 1954);5-Aziridino-2,4-dinitrobenzamide
- CBNumber:
- CB31216241
- Summenformel:
- C9H8N4O5
- Molgewicht:
- 252.18
- MOL-Datei:
- 21919-05-1.mol
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5-Aziridino-2,4-dinitrobenzamide Eigenschaften
- Schmelzpunkt:
- 173 °C
- Siedepunkt:
- 427.2±45.0 °C(Predicted)
- Dichte
- 1.671±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 14.23±0.50(Predicted)
- Aggregatzustand
- solid
- Farbe
- Yellow to Dark Yellow
- InChIKey
- WOCXQMCIOTUMJV-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2933.99.7500 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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5-Aziridino-2,4-dinitrobenzamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.
Verwenden
5-Aziridino-2,4-dinitrobenzamide is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.
Biochem/physiol Actions
CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase?2.
5-Aziridino-2,4-dinitrobenzamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Aziridino-2,4-dinitrobenzamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 92)Lieferanten
21919-05-1()Verwandte Suche:
- 5-(1-aziridinyl)-2,4-dinitrobenzamide
- NSC 115829
- tretazicar
- 5-(1-Aziridinyl)-2,4-dinitrobenzamide, 5-(Aziridin-1-yl)-2,4-dinitrobenzamide
- 5-Aziridino-2,4-dinitrobenzamide
- 2,4-Dinitro-5-(aziridine-1-yl)benzamide
- CB-954
- CB-1954
- 5-(Aziridin-1-yl)-2,4-dinitrobenzamide
- Benzamide, 5-(1-aziridinyl)-2,4-dinitro-
- 2,4-Dinitro-5-ethyleneiminobenzamide
- Tretazicar (>94%)
- Tretazicar (CB 1954)
- CB 1954;CB-1954
- CB1954(TRETAZICAR)
- Tretazicar (>
- Tretazicar,NQO1,DNA Alkylator/Crosslinker,rat,bifunctional,Inhibitor,inhibit,agent,cross-link,256,line,4-hydroxylamine,Walker,CB 1954,DNA,CB-1954,tumour
- 21919-05-1
