Temocapril hydrochloride
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- CAS-Nr.
- 110221-44-8
- Englisch Name:
- Temocapril hydrochloride
- Synonyma:
- CS-622;Acecol;CS-622 HCl;TemocarpileHCL;Temocapril Hcl;Carbovir Impurity 4;Temocarpilhydrochloride;TEMOCAPRIL HYDROCHLORIDE;CS-622 HCl|Temocapril HCl;Temocapril hydrochloride, >=99%
- CBNumber:
- CB2841030
- Summenformel:
- C23H28N2O5S2.ClH
- Molgewicht:
- 513.076
- MOL-Datei:
- 110221-44-8.mol
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Temocapril hydrochloride Eigenschaften
- Schmelzpunkt:
- 196-2000C (dec)
- alpha
- 25D +47.7° (c = 1 in DMF)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- CAS Datenbank
- 110221-44-8(CAS DataBase Reference)
Sicherheit
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| Toxizit?t |
LD50 in mice, rats, dogs (mg/kg): >5000, >5000, >800 orally (Koike) |
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Temocapril hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Temocapril is a novel ACE inhibitor marketed in Japan for the treatment of
hypertension. Temocapril is three times more potent than enalapril by oral
administration, and has a long duration of action. It is characterized by a rapid onset
of action resulting from a fast conversion of temocapril to the active metabolite
diacid. Unlike most ACE inhibitors which are excreted mainly through the kidneys,
temocapril is excreted predominantly through the biliary route indicating that
temocapril is especially useful for treating hypertensive patients with renal
dysfunction. The potential usefulness of temocapril in the treatment of congestive
heart failure has been reported.
Chemische Eigenschaften
White To Off-White Solid
Temocapril hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Temocapril hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 179)Lieferanten
110221-44-8()Verwandte Suche:
- TEMOCAPRIL HYDROCHLORIDE
- Acecol
- CS-622
- 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI)
- 1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-
- Temocapril Hcl
- TemocarpileHCL
- Temocarpilhydrochloride
- (2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride
- (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride
- (2S,6R)-6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid,hydrochloride (1:1)
- CS-622 HCl
- Temocapril hydrochloride, >=99%
- 2-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)-2,5,6,7-tetrahydro-1,4-thiazepine-4(3H)-yl]acetic acid·hydrochloride
- 1,4-Thiazepine-4(5H)-aceticacid,6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-,hydrochloride (1:1), (2S,6R)-
- Temocapril HCl and intermediates
- 2-[6-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid hydrochloride
- Temocapril hydrochloride USP/EP/BP
- TIANFU-CHEM - Temocapril hydrochloride
- 2-((2S,6R)-6-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)acetic acid hydrochloride
- Carbovir Impurity 4
- CS-622 HCl|Temocapril HCl
- 110221-44-8
- 10221-44-8
- 110221-48-8
- C23H28N2O5S2HCl
- C23H28N2O5S2xHCl
- C23H29ClN2O5S2
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
