SUCCINYL COENZYME A SODIUM SALT
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- CAS-Nr.
- 108347-97-3
- Englisch Name:
- SUCCINYL COENZYME A SODIUM SALT
- Synonyma:
- Succinyl CoA, Li-salt;Succinyl-CoA-sodium-salt;succinyl coenzyme A sodium;SUCCINYL COENZYME A SODIUM SALT;Succinyl coenzyme A sodium salt >=85%;coenzyme A succinyl derivative, trisodium salt;Coenzyme A,S-(hydrogen butanedioate),sodium salt;Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)
- CBNumber:
- CB2444570
- Summenformel:
- C25H41N7NaO19P3S
- Molgewicht:
- 891.6
- MOL-Datei:
- 108347-97-3.mol
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SUCCINYL COENZYME A SODIUM SALT Eigenschaften
- storage temp.
- -20°C
- L?slichkeit
- PBS (pH 7.2): 10 mg/ml
- Aggregatzustand
- A crystalline solid
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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SUCCINYL COENZYME A SODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle. It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis. Succinyl-CoA deficiency, caused by vitamin B
12 deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.
Verwenden
Succinyl coenzyme A sodium salt has been used:
- for the nonenzymatic succinylation of lysine in vitro,
- as a substrate for adipic acid biosynthesis in recombinant E. coli
- in isocitrate dehydrogenase (ICDH)?treatment for the succinylation of proteins
- as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)
l?uterung methode
If it should be purified further, then it should be dissolved in H2O (0.05g/mL) adjusted to pH 1 with 2M H2SO4 and extracted several times with Et2O. Excess Et2O is removed from the aqueous layer by bubbling N2 through it and is stored frozen at pH 1. When required, the pH should be adjusted to 7 with dilute NaOH and used within 2 weeks (samples should be frozen). Succinyl coenzyme A is estimated by the hydroxamic acid method [Hersch & Jencks J Biol Chem 242 3468 1967]. It is more stable in acidic than in neutral aqueous solutions, but neutral solutions can be stored at –15o with negligible decomposition. [Jordan & Laghai-Newton Methods Enzymol 123 435 1986, Beilstein 26 III/IV 3666.]
SUCCINYL COENZYME A SODIUM SALT Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SUCCINYL COENZYME A SODIUM SALT Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 35)Lieferanten
108347-97-3()Verwandte Suche:
- SUCCINYL COENZYME A SODIUM SALT
- succinyl coenzyme A sodium
- coenzyme A succinyl derivative, trisodium salt
- Succinyl CoA, Li-salt
- Succinyl coenzyme A sodium salt >=85%
- Coenzyme A,S-(hydrogen butanedioate),sodium salt
- Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)
- Succinyl-CoA-sodium-salt
- 108347-97-3
- C25H38N7Na2O19P3S
- Metabolic Libraries
- Lipid Library
- Metabolomics
- BioChemical
- Aminolevulinate synthase, 5-Saturated fatty acids and derivatives
- Cofactors
- Enzymes, Inhibitors, and Substrates
- Esters
- Fatty acyl CoAsMetabolic Pathways
- Lipid Library
- LipidMetabolomics
- Metabolic Libraries
- Metabolites and Cofactors on the Metabolic Pathways Chart
- Substrates by Enzyme
- Acyl Transfer ReagentsEnzyme Substrates