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Coenzym A

Coenzyme A Struktur
85-61-0
CAS-Nr.
85-61-0
Bezeichnung:
Coenzym A
Englisch Name:
Coenzyme A
Synonyma:
COA;COA-SH;COENZYME A HYDRATE;Lucina;Coalip;Aluzime;Thiol-CoA;SHUIRUJIE;COENZYME A;CONENZYME A
CBNumber:
CB8854470
Summenformel:
C21H36N7O16P3S
Molgewicht:
767.53
MOL-Datei:
85-61-0.mol

Coenzym A Eigenschaften

Dichte
1.96±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
PBS (pH 7.2): 10 mg/ml
Aggregatzustand
A crystalline solid
pka
9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
Farbe
White to light yellow
Merck 
13,2491
BRN 
77809
InChIKey
RGJOEKWQDUBAIZ-IBOSZNHHSA-N
SMILES
SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O
LogP
-4.358 (est)
EPA chemische Informationen
Coenzyme A (85-61-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 24/25
WGK Germany  3
1-10
TSCA  Yes
HS Code  2933299090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P321 Besondere Behandlung
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P362 Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

Coenzym A Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Chemische Eigenschaften

yellowish lyophilisate

Verwenden

A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.

Definition

ChEBI: Coenzyme A is a thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. It has a role as an Escherichia coli metabolite, a mouse metabolite and a coenzyme. It is functionally related to an ADP. It is a conjugate acid of a coenzyme A(4-).

Allgemeine Beschreibung

Coenzyme A (CoA) is a cofactor with a molecular weight of 797 Da. Its biological structure is formed from pantothenic acid (vitamin B5), cysteine and adenosine triphosphate through an evolutionarily conserved pathway. CoA is primarily involved in cellular oxidative pathways, including fatty acid beta-oxidation, carbohydrate, amino acid oxidation, and the Krebs cycle; as well as in lipid synthesis, protein modification, and membrane transport. CoA serves as a carrier for the activation of acyl groups, which can be transferred to amides, esters, or acid anhydrides. CoA can also be regulate a variety of metabolic processes at different levels as substrates, allosteric regulators, and through post-translational modifications of histones and other non-histone proteins. It is an essential cofactor in all organisms.

l?uterung methode

The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]

Coenzym A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Coenzym A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 301)Lieferanten
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85-61-0(Coenzym A)Verwandte Suche:


  • Lucina
  • Thiol-CoA
  • Coenzyme A,75%,free acid, lyophilized
  • Coenzyme A, free acid, hydrate (COA)
  • coenzyme A(4-)
  • COENZYME A
  • [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
  • CONENZYME A
  • Coenzyme a, free acid
  • Coenzyme A, free acid, lyophilized, min. 75% (enzym.)
  • COENZYME A FREE ACID FROM YEAST
  • Coenzyme A, free acid, lyophilized, 75%
  • Coenzyme A / Q0 / Q10
  • COENZYM A FREE ACID
  • COENZYME A (COA)
  • CoenzyMe A hydrate (free acid)
  • Coenzyme A hydrate,CoA
  • [5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
  • Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester
  • Aluzime
  • Coenzyme ASH
  • D-Coenzyme A
  • Coalip
  • SHUIRUJIE
  • Coenzyme A, Free Acid(CoA)
  • COENZYMEA 96%, TRILITH. D1GM
  • Coenzyme A USP/EP/BP
  • (((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy((R)-3-hydroxy-2,2-dimethyl-3-((2-((2-sulfanylethyl)carbamoyl)ethyl)carbamoyl)propoxy)phosphoryl)oxy)phosphoryl)oxy)methyl)oxolan-3-yl)oxy)phosphonic acid
  • Delivery Coenzyme
  • CoASH (Coenzyme A-SH), 80%
  • [[(2S,3R,4S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
  • COENZYME A HYDRATE
  • COA
  • COA-SH
  • Coenzyme A (8CI, 9CI, ACI)
  • Acetyl Coenzyme
  • 85-61-0
  • 85-16-0
  • C21H36N7O16P3S
  • C21H36N7O16P3S3H2O
  • C21H38N7O17P3S
  • C21H32N7O16P3S
  • C21H36N7O16P3SxH2O
  • C21H36N7O16P3SH2O
  • Metabolic Libraries
  • Lipid Library
  • Nucleosides, Nucleotides, Oligonucleotides
  • Biochemicals and Reagents
  • BioChemical
  • Coenzyme A and Derivatives
  • Metabolomics
  • Vitamin series
  • 85-61-0
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