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Berberin

Berberine Struktur
2086-83-1
CAS-Nr.
2086-83-1
Bezeichnung:
Berberin
Englisch Name:
Berberine
Synonyma:
BERBERINE HCL;BBR;berberin;250Mg;BERBERIN HCL;Coptis chinensis extract;5,6-DIHYDRO-9,10-DIMETHOXY-BENZO[G]-1,3-BENZODIOXOLO[5,6-A]QUINOLIZINIUM, CHLORIDE;CI 75160;beriberi;BERBERINE
CBNumber:
CB2319032
Summenformel:
C20H18NO4
Molgewicht:
336.37
MOL-Datei:
2086-83-1.mol

Berberin Eigenschaften

Schmelzpunkt:
204-206 °C (dec.)
Siedepunkt:
486.8°C (rough estimate)
Dichte
1.2976 (rough estimate)
Brechungsindex
1.5800 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Aggregatzustand
powder
pka
2.47(at 25℃)
Farbe
White to yellow crystals
Wasserl?slichkeit
43.48g/L(25 ºC)
LogP
-0.990 (est)
CAS Datenbank
2086-83-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  1544
WGK Germany  2
RTECS-Nr. DR9866400
3-10
HazardClass  6.1(b)
PackingGroup  III
Toxizit?t LD50 orl-mus: 329 mg/kg YKKZAJ 82,726,62
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Berberin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Coptis chinensis was widely used in China as a folk medicine by Shennong around 3000 BC. Coptis chinensis was firstly described in the ancient Chinese medical book The Divine Farmer’s Herb-Root Classic. Coptis chinensis was used to treat intestinal bacterial infections and antipyretic analgesic for thousands of years ago
Coptis chinensis also called zhilian, chuanlian, weilian, jizhualian, shanglian, and xuanlian in Chinese history. Coptis chinensis was accepted by most physicians, and the Chinese pharmacopoeia also uses Coptis chinensis as its official name . Coptis chinensis mainly grows in Anhui, Hunan, Sichuan, and Yunnan and has been cultivated in Sichuan since the Ming dynasty, which has a long history of cultivation. Other species of Coptis chinensis from different places were used as medicine. However, commodity circulation of wild Rhizoma coptidis has not been formed . Coptis chinensis is national three level protection plants at present and majorly produced in Shizhu of Chongqing, West Hubei, Shanxi, and Gansu.
Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in some plants such as huanglian 黃連 (Rhizoma coptidis), huangbo黃柏 (Phellodendri Chinensis Cortex), sankezhen三顆針 (Berberidis Radix), and so on.
The components of Coptis chinensis which have antibacterial and antiinflammatory effects are original alkaloid berberine class, including berberine, coptisine, palmatine, epiberberine, columbamine, jatrorrhizine, worenine, and magnoflorine, with berberine having the highest content (5–8%).

Chemische Eigenschaften

White to yellow crystals. Iinsoluble in water; soluble in ether, alcohol. Salts of berberine are berberine bisulfate, berberine sulfate, and berberine hydrochloride. All three are yellow crystals, slightly soluble in water.

Physikalische Eigenschaften

Appearance: Berberine is odorless and yellow crystalline powder. Solubility: Berberine is soluble in hot water, slightly soluble in water or ethanol and in chloroform, and insoluble in ether. Melting point: Melting point of berberine is about 204–206?°C.?Berberine is heat labile.

History

Berberine is often used in the form of quaternary ammonium alkali. The solubility of berberine in water is lower, for example, berberine hydrochloride is 1:500, and berberine sulfate is 1:30. In 1926, berberine was first separated from bark of Zanthoxylum clava. Modern pharmacology study showed that berberine has defined structure and is a monomer of traditional Chinese medicine. Berberine can be obtained from many sources and is used in clinics, with reliable pharmacological effects and various and unique mechanisms.
At present, berberine can be synthesized by industrial biosynthesis. A series of derivatives can also be synthesized by structure modification, and the pharmacological activities of these derivatives have been tested.

Verwenden

Antiseptic drug.Treat intestinal infection caused from dysentery bacillus and E.coil

Weltgesundheitsorganisation (WHO)

Berberine, an alkaloid contained in many plants including Berberis species, remains available in many tropical countries. Both traditional herbal remedies and tablet formulations containing this substance have been used in the treatment of gastrointestinal disease, and injectable preparations have been claimed to be of value in the treatment of cutaneous leishmaniasis. The action taken in Singapore relates to reports of jaundice, haemolytic anaemia and kernicterus with brain damage in infants with G6PD deficiency who were exposed either in utero or post-natally. Preparations for topical application are also available in some countries. These have not been associated with reports of systemic toxicity.

Hazard

Toxic via ingestion, inhalation, skin absorption.

Pharmakologie

Berberine hydrochloride has extensive pharmacological effects, such as antibacterial, antiviral, anti-inflammatory, analgesic, anticancer, hyperglycemic, antilipidemic, antihypertension, anti-arrhythmic, anti-heart failure, and so on. Experimental study and clinical reports demonstrate that berberine has therapeutic effect on the endocrine system, circulatory system, nervous system, digestive system, and respiratory system and other diseases.
The clinical indication of berberine is intestinal bacterial infectious diarrhea, which is confirmed by years of clinical application. Berberine hydrochloride exerts effect on intestinal infection, eye conjunctivitis, and suppurative otitis media induced by Shigella dysenteriae, Escherichia coli, and Staphylococcus aureus and ameliorates gastritis and combined gastric and duodenal ulcers. Berberine hydrochloride also has curative effect on acute lung injury, pneumonia, and other respiratory diseases; peptic ulcer, colitis, and other digestive system diseases; pregnancy, urinary, and reproductive system infections; and other urinary tract and reproductive system diseases.

Clinical Use

Rhizoma coptidis, as the digestive tract disease medication, has a history of more than 3000?years in China and India. Berberine, as a cathartic nonprescription drug, is mainly used in the treatment of intestinal infection clinically. Clinical research showed that berberine has hypoglycemic effect and has very good prevention and treatment for diabetic patients with complications such as hypertension, hyperlipidemia, thrombosis, and inflammation
There are few oral side effects of berberine hydrochloride, accidentally appears nausea, vomiting, rash, and fever, which can disappear after withdrawal of drug. In patients with hemolytic anemia and lack of glucose-6-phosphate dehydrogenase, it was forbidden to be used. Berberine if used intravenously is toxic, but is only suitable for oral drug delivery .

Sicherheitsprofil

An alkaloid poison by ingestionand subcutaneous routes. In humans, toxic doses lowerthe body temperature, increase peristalsis, and cause deathby central paralysis. Mutation data reported. Should carry apoison label. Should never be ingested without t

l?uterung methode

Berberine crystallises from pet ether or ether as yellow needles or from H2O. [Beilstein 27 II 567, 27 III/IV 6539.]

Berberin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Berberin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 335)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838
evan@tyvovo.com China 148 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+8615350851019
admin@86-ss.com China 1001 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2789 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967
kaia@neputrading.com China 1001 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58

2086-83-1(Berberin)Verwandte Suche:


  • BERBERINE
  • BERBERINE HYDROCHLORIDE N-HYDRATE
  • CI 75160
  • LABOTEST-BB LT00440956
  • NATURAL YELLOW 18 CHLORIDE
  • TIMTEC-BB SBB006488
  • UMBELLATINE
  • 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6]quinolizinium
  • 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
  • Berberine (base and/or unspecified salts)
  • Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-
  • 7,8,13,13a-Tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium
  • Berbericine
  • 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium
  • Rhizoma Coptidis extract
  • 7,8,13,13a-tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-berbiniu
  • 9,10-dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium
  • InsipBerberine
  • Coptisrootextract
  • 7,8,13,13-Tetradehydro-9.10-dimethoxy-2,3-(methylenedioxy)berbinium
  • Coptis extract
  • Chinese Goldthread Extract
  • Dried Coptidis Rhizoma Extract
  • Berberine USP/EP/BP
  • Berberine iodide salt
  • 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium DISCONTINUED. offer B318150
  • beriberi
  • Berberine D6
  • 2086-83-1 Berberine
  • 5,6-DIHYDRO-9,10-DIMETHOXY-BENZO[G]-1,3-BENZODIOXOLO[5,6-A]QUINOLIZINIUM, CHLORIDE
  • BERBERINE HCL
  • BERBERIN HCL
  • BBR
  • 250Mg
  • berberin
  • Coptis chinensis extract
  • 3-Oxo-5β-cholanoic acid sodium
  • Berberine (unspecified form)
  • 2086-83-1
  • 663-65-8
  • C20H18ClNO4
  • C20H18NO4
  • C20H18ClNO4nH2O
  • BioChemical
  • Anti-Proliferative Agents
  • Antitumor Agents
  • Cancer Research
  • Alkaloids
  • Isoquinoline Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • sy
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