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ANTISAUVAGINE-30

ANTISAUVAGINE-30 Struktur
220673-95-0
CAS-Nr.
220673-95-0
Englisch Name:
ANTISAUVAGINE-30
Synonyma:
ANTISAUVAGINE-30;PubChem ID: 90471086;M.W. 3650.29 C161H274N48O46S;(D-Phe??,His??)-Sauvagine (11-40);(D-PHE11,HIS12)-SAUVAGINE (11-40);11-D-Phenylalanine-12-L-histidine-11-40-sauvagin;(D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT;D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
CBNumber:
CB2314057
Summenformel:
C161H273N47O47S
Molgewicht:
3651.24
MOL-Datei:
220673-95-0.mol

ANTISAUVAGINE-30 Eigenschaften

RTECS-Nr.
VQ6120000
storage temp. 
−20°C
Aggregatzustand
Powder
Wasserl?slichkeit
Soluble to 1 mg/ml in water

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3

ANTISAUVAGINE-30 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Enzyminhibitor

This highly selective CRF2 antagonist (MW = 3650.29 g/mol; CAS 220673-95-0; Sequence: D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile- Glu-Lys-Gln-Glu-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2; Solubility: 5 mg/mL H2O; Alternate Name: [D-Phe 11 ,His 12 ]-Sauvagine (11- 40)) targets human Corticotropin-Releasing hormone (CRH) Receptor-2 subtypes CRF2β (Ki = 1.4 nM), with a much higher value of 154 nM for CRF1. (See also Astressin; K41448) Type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Antisauvagine-30 blocks (pA2 = 8.49) sauvagine-stimulated accumulation of cAMP in HEK-mCRF2β cells. It also prevents stress-enhanced fear conditioning and MEK1/2- dependent activation of ERK1/2 in mice and suggesting a role for protein kinase signaling in the hippocampus and its modulation by CRF2 as a possible link between stress and fear memory.

ANTISAUVAGINE-30 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTISAUVAGINE-30 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 60)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10311 58
Cellmano Biotech Limited
0551-65326643 18156095617
info@cellmano.com China 999 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30238 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634
Cecilia@youngshechem.com China 2345 58
Nanjing Doge Biomedical Technology Co., Ltd
+86-25-58227606 +86-15305155328
sales@dogechemical.com China 4128 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150
support@tgpeptide.com China 3279 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599
info@molchanges.com China 5223 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15839 69

220673-95-0()Verwandte Suche:


  • D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
  • (D-PHE11,HIS12)-SAUVAGINE (11-40)
  • (D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT
  • H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH
  • H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
  • ANTISAUVAGINE-30
  • M.W. 3650.29 C161H274N48O46S
  • 11-D-Phenylalanine-12-L-histidine-11-40-sauvagin
  • PubChem ID: 90471086
  • (D-Phe??,His??)-Sauvagine (11-40)
  • 220673-95-0
  • C161H273N47O47S
  • CRF receptor and related
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