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Luminespib

Luminespib Struktur
747412-49-3
CAS-Nr.
747412-49-3
Englisch Name:
Luminespib
Synonyma:
CS-209;AUY 922;VER-52296;VER 52296;LuMinespib;NVP-AUY922;NVP-AUY922-NX;AUY922, VER-52296;NVP-AUY922, >=98%;AUY922 (NVP-AUY922)
CBNumber:
CB22489931
Summenformel:
C26H31N3O5
Molgewicht:
465.54
MOL-Datei:
747412-49-3.mol

Luminespib Eigenschaften

Schmelzpunkt:
180-184°C
Siedepunkt:
640.1±55.0 °C(Predicted)
Dichte
1.234
storage temp. 
-20°C
L?slichkeit
Soluble in DMSO (>25 mg/ml)
Aggregatzustand
solid
pka
8.47±0.48(Predicted)
Farbe
White
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS Datenbank
747412-49-3
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2934999090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Luminespib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition has been associated with the degradation of oncogenic client proteins. NVP-AUY922 is a Hsp90 inhibitor (IC50 = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines in vitro with GI50s averaging 9 nM. In a human colon cancer xenograft model, 50 mg/kg NVP-AUY922 inhibits tumor growth by ~50% compared to vehicle controls. Unlike some first generation Hsp90 inhibitors that are quickly glucuronidated, NVP-AUY922 is retained in tumors in vivo when administered at 4 mg/kg i.p. by cassette dosing in tumor-bearing mice.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine.

Luminespib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Luminespib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 155)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29884 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32080 58
Hubei Ipure Biology Co., Ltd 		+8613367258412
 ada@ipurechemical.com China 10319 58

747412-49-3()Verwandte Suche:

  • 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
  • AUY922 (NVP-AUY922)
  • VER 52296
  • VER-52296
  • NVP-AUY922
  • AUY 922
  • LuMinespib
  • Luminespib (AUY-922, NVP-AUY922)
  • AUY922,NVP-AUY-922,Luminespib
  • 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide
  • 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide AUY922 (NVP-AUY922)
  • Luminespib (NVP-AUY922)
  • AUY922, VER-52296
  • NVP-AUY922, >=98%
  • NVP-AUY922, Luminespib, VER52296
  • 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxam
  • 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide USP/EP/BP
  • 3-Isoxazolecarboxamide, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-
  • 17-AAG, Hsp90 inhibitor
  • NVP-AUY922, Hsp90 Inhibitor
  • AUY922; AUY-922; AUY 922; NVP AUY922; NVP AUY-922; VER52296 ; VER-52296 ; VER 52296 ; LUMINESPIB
  • LUMINESPIB;NVP-AUY922;VER-52296;NVP-AUY 922;AUY-922;VER 52296;VER52296
  • AUY922 (Luminespib,NVP-AUY922)
  • NVP-AUY922 - VER 52296 | Luminespib
  • NVP-AUY922-NX
  • AUY 922;AUY-922; NVP-AUY922;NVP-AUY922-NX;AUY922;VER-52296
  • CS-209
  • NVP-AUY922 (Luminespib
  • AUY-922 (LUMINESPIB)
  • AUY-922,Luminespib,AUY 922,Inhibitor,HSP,Autophagy,Heat shock proteins,VER52296,Apoptosis,inhibit,VER 52296
  • Luminespib(VER-52296
  • 747412-49-3
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitor
  • Potent and oral inhibitor of heat shock protein 90.
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Antineoplastic
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