(-)-Epigallocatechin gallate
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- CAS-Nr.
- 989-51-5
- Englisch Name:
- (-)-Epigallocatechin gallate
- Synonyma:
- EGCG;EPIGALLOCATECHIN GALLATE;ECGC;(-)-Epigallocatechin-3-O-gallate (20 mg);epigallocatechin3-gallate;Epigallocatechin-3-Monogallate;(-)-epigallocatechin 3-gallate;E-5187;(EGCE);EGCG-d6
- CBNumber:
- CB2227188
- Summenformel:
- C22H18O11
- Molgewicht:
- 458.37
- MOL-Datei:
- 989-51-5.mol
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(-)-Epigallocatechin gallate Eigenschaften
- Schmelzpunkt:
- 222-224°C
- alpha
- D -185 ±2°(ethanol)
- Brechungsindex
- -175.5 ° (C=1, EtOH)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: ≥5mg/mL, clear
- Siedepunkt:
- 909.1±65.0 °C(Predicted)
- Dichte
- 1.90±0.1 g/cm3(Predicted)
- pka
- 7.75±0.25(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Light Brown
- Wasserl?slichkeit
- Soluble in ethanol, dimethyl formamide, water.
- Merck
- 14,3526
- Stabilit?t:
- Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
- InChIKey
- WMBWREPUVVBILR-WIYYLYMNSA-N
- LogP
- 0.639 (est)
- CAS Datenbank
- 989-51-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
24/25 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
KB5200000 |
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| F |
10-23 |
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| HS Code |
29339900 |
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| Toxizit?t |
LD50 oral in mouse: 2170mg/kg |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H411 |
Giftig für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 2 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(-)-Epigallocatechin gallate Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
solid
Verwenden
(-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid-β and amaloid plaques in mice. This compound has neuroprotective properties.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Epigallocatechin gallate is a potent polyphenolic flavonoid which is found as a component of tea. It exhibits antioxidant, antimutagenic, antitumor and anti-inflammatory properties, thereby contributing to the health-beneficial actions. It finds potential use as a drug candidate in the pharmaceutical, cosmetic, and nutritional fields.
Hazard
Moderately toxic by ingestion.
Anticancer Research
EGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin. Hesperetin, quercetin,daidzein, silymarin, naringenin, and resveratrol also inhibit the MRP1, MRP4, andMRP5 (Kawasaki et al. 2008). Curcumin increases the cellular accumulation ofanticancer agents like cisplatin, tamoxifen, daunorubicin, vincristine, anddoxorubicin and thereby effectively sensitizes the drug-resistant cancer cells. Areduction in MDR1B expression in L1210/Adr cells (mouse leukemic MDR cells)by curcumin is mediated by PI3K, Akt, and NF-κB pathways. It also inhibits theABCG2 transporter activity. In addition curcumin facilitates the accumulation ofmitoxantrone and doxorubicin in ABCG2-expressing HEK cells and hence reversesMDR (Kawasaki et al. 2008; Dandawate et al. 2013).
(-)-Epigallocatechin gallate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(-)-Epigallocatechin gallate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 597)Lieferanten
989-51-5()Verwandte Suche:
2-(3,4-Dihydroxyphenyl)-2,3,4-trihydro-3,5,7-trihydroxychromen
Propyl-3,4,5-trihydroxybenzoat
1,2,3-Trihydroxybenzol
Gallic acid monohydrate
Methyl-3,4,5-trihydroxybenzoat
2,6-Dimethyloct-7-en-2-ol
3,4,5-Trihydroxybenzoesure
- TEA CATECHIN
- EGCG, (-)-Epigallocatechin gallate/Green Tea EGCG90
- EGCG, (-)-Epigallocatechin gallate/Green Tea Extract
- (-)-CIS-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3 ,5,7-TRIOL 3-GALLATE
(-)-CIS-3,3',4',5,5',7-HEXAHYDROXY-FLAVANE-3-GALLATE
- L-Epigallocatechin Gallate
- (-)-Epigallocatechin Gallate-d6
- 3-O-Galloyl-(-)-epigallocatechin-d6
- EGCG-d6
- epi-Gallocatechin 3-O-Gallate-d6
- epi-Gallocatechin Gallate-d6
- Epigallocatechin-3-Monogallate-d6
- L-Epigallocatechin Gallate-d6
- (-)-cis-3,4-Dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2H)-benzopyran-3-yl Gallate
EGCG
- Teatannin II
- EGCG, (-)-Epigallocatechin gallate/Green Tea EGCG95
- 3-(3,4,5-TRIHYDROXYBENZOATE)
- Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
- (-)-epigallocatechin-3-o-gallate
- (-)-epigallocatecholgallate
- 3-gallate,(-)-epigallocatecho
- Epigallocathecinfromgreentea
- EGCG (epigallocatechin gallate)
- EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 50% BY HPLC
- TEAVIGO(TM)
- EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 95% BY HPLC
- EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 30% BY HPLC
- EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 98% BY HPLC
- EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 70% BY HPLC
- EPIGALLOCATECHIN GALLATE, (EGCG) FROM GREEN TEA 90% BY HPLC
- EGCG: E-5187(-)-EPIGALLOCATECHIN GALLATE
- Egcg90%
- EpigallocatechinGallate(Egcg)
- (-)-cis-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2h)-benzopyran-3-yl gallate
- (-)-epigallocatechin gallate from green tea
- EPIGALLOCATCCHINGALLATE
- [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate
- EPIGALLOCATECHIN GALLATE, (-)- SNAPN 0.1mg/mL(SH)
- EPIGALLOCATECHIN GALLATE, (-)-(P)
- EPIGALLOCATECHIN GALLATE, (-)-(SH)
- (-)-EPIGALLOCATECHIN GALLATE hplc
- (-)EPIGALLOCATECHIN GALLATE WITH HPLC
- Green tea extract/EGCG
- Benzoicacid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-
- dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-ylester,(2R-cis)-
- EGCG, (-)-cis-3,3μ,4μ,5,5μ,7-Hexahydroxy-flavane-3-gallate, (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate
- (-)-Epigallocatechin gallate ,98%
- 3,4,5-Trihydroxybenzoic acid [(2R,3R)-3,4-dihydro-5,7-dihydroxy-2α-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3α-yl] ester
- (-)-Epigallocatehin gallate
- EGCG(Green Tea Extract)
- [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
- 3,4,5-trihydroxybenzoic acid [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] ester
- epigallocathequin gallate
- ()-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate
(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(
- ()-Epigallocatechin gallate,()-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, ()-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate, EGCG
- 3-O-Galloyl-(-)-epigallocatechin
- Epigallocatechin 3-galla
- Teavigo
- Teavigo TG
