Methyl 4-chloropicolinate
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- CAS-Nr.
- 24484-93-3
- Englisch Name:
- Methyl 4-chloropicolinate
- Synonyma:
- 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;METHYL 4-CHLOROPYRIDINE-2-CARBOXYLATE;4-chloropicolinate;EOS-62380;IFLAB-BB F2108-0101;oro-2-pyridinecarboxyL;Methyl 4-chloropicolite;METHYL 4-CHLOROPICOLINATE;4-chloropyridine-2-formate;Methyl 4-Chloro-2-picolinate
- CBNumber:
- CB2224066
- Summenformel:
- C7H6ClNO2
- Molgewicht:
- 171.58
- MOL-Datei:
- 24484-93-3.mol
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Methyl 4-chloropicolinate Eigenschaften
- Schmelzpunkt:
- 50-52
- Siedepunkt:
- 105-111 °C(Press: 2-3 Torr)
- Dichte
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- -0.25±0.10(Predicted)
- Farbe
- Off-White to Beige
- InChI
- InChI=1S/C7H6ClNO2/c1-11-7(10)6-4-5(8)2-3-9-6/h2-4H,1H3
- InChIKey
- VTENWIPSWAMPKI-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=CC(Cl)=C1
- CAS Datenbank
- 24484-93-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36 |
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| S-S?tze: |
26 |
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| HazardClass |
IRRITANT |
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| HS Code |
2933399990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Methyl 4-chloropicolinate Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Brown Solid
Verwenden
Methyl 4-Chloropicolinate (cas# 24484-93-3) is a compound useful in organic synthesis.
Vorbereitung Methode
The starting material 2-picolinic acid was treated with SOCl2 to generate 4-chloropicolinoyl chloride, and then esterification with MeOH resulted in the formation of methyl 4-chloropicolinate.
Synthesis Reference(s)
Synthetic Communications, 26, p. 2017, 1996
DOI: 10.1080/00397919608003557
Synthese
To a suspension of 4-chloropyridine-2-carboxylic acid (4.5 g, 29.0 mmol) in methylene chloride (120 mL) was added oxalyl chloride (3.0 mL, 1.2 eq) under Ar2. The reaction was cooled to 0° C., and 500 uL of DMF was added. A large amount of gas was generated in situ. The reaction was stirred at room temperature for 1.5 h and then concentrated. Dry MeOH (50 mL) was added to the crude acyl chloride residue. The reaction was stirred at room temperature for 0.5 h, then quenched with NaHCO3 (5%) to neutral, extracted with EtOAc, and washed with brine. The combined organics were dried over MgSO4, filtered, and concentrated in vacuo to give 5.0 g of a crude solid, which was triturated with 5% EtOAc/hexane to give Methyl 4-chloropicolinate as a light yellow solid (4.5 g, 90%).
Methyl 4-chloropicolinate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methyl 4-chloropicolinate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 482)Lieferanten
24484-93-3()Verwandte Suche:
- IFLAB-BB F2108-0101
- METHYL 4-CHLOROPICOLINATE
- 4-Chloropyridine-2- forMic acidMethyl ester
- Methyl 4-chloropicolite
- Methyl 4-chloropyridine-2-carboxylate 97%
- METHYL 4-CHLORO-2-PYRIDINECARBOXYLATE
- 6-Methyl-2-(trifluoromethanesulfonyl)Oxypyridine
- Methyl 4-Chloro-2-picolinate
- 4-Chloropicolinic Acid Methyl Ester
Methyl 4-Chloropicolinate
4-Chloro-2-pyridinecarboxylic Acid Methyl Ester
- 2-Pyridinecarboxylic acid, 4-chloro-, methyl ester
- 4-Chloropicolinic Acid Methyl Ester
- 4-Chloro-pyridine-2-carboxylic acid methyl
- Methyl 4-chloro-2-pyridin...
- Methyl 4-chloropicolinate, 4-Chloro-2-(methoxycarbonyl)pyridine
- Methyl 4-chloropyridine-2-car
- EOS-62380
- oro-2-pyridinecarboxyL
- Methyl4-Chloro-2-pyridinecarboxylate>
- 4-chloropyridine-2-formate
- Methyl 4-chloropicolinate ISO 9001：2015 REACH
- 4-chloropicolinate
- METHYL 4-CHLOROPYRIDINE-2-CARBOXYLATE
- 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- 4-chloropyridine-2-carboxylic acid methyl ester (intermediate of sorafenib)
- 4-Chloro pyridine-2-carboxylic acid ME
- 4-Chloro pyridine carboxylic acid methylester
- 24484-93-3
- 24482-93-3
- pharmacetical
- Pyridine
- Aromatics Compounds
- Aromatics
- Bases & Related Reagents
- Nucleotides
- Pharmaceutical intermediate
- blocks
- Carboxes
- Pyridines
- Acids and Derivatives
- Heterocycles
- Picolinic acid series
- OLED materials,pharm chemical,electronic
