L-Norephedrin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
This alkaloid was first isolated by Kanao from the Chinese drug 'Ma-Huang'
(Ephedra sinica Stapf.) and later by Wolfes from E. helvetica C. A. Meyer and E.
distachya Linn. It forms a crystalline mass and has [α]
20
D - 14.56° (EtOH).
Several crystalline salts and derivatives are known: the hydrochloride has m.p.
171-2°C; [α]
20
D- 33.27° (H20); the sulphate dihydrate, m.p. 285-6°C (dry,
dec.); [α]
28
D- 31.99° (H20); the aurichloride, m.p. 188°C; platinichloride, m.p.
221°C (dec.); (-)-hydrogen tartrate, m.p. about 160° after sintering at 130°C;
oxalate, m.p. 245°C (dec.) and the p-nitrobenzoyl derivative, m.p. 175-6°C;
[α]
28
D- 49.58° (CHCI3).
The (+)-form has m.p. 52°C; [α]
27
D + 14.76° (EtOH), yielding a hydro_x0002_chloride, m.p. 171-2°C; [α]
27
D + 33.4° (EtOH); sulphate dihydrate, m.p. 285-
6°C (dry, dec.); [α]
27
D+ 31.51 0 C (H20); aurichloride, m.p. 188°C (dec.) and
platinichloride, m.p. 221.5°C (dec.). The (±)-form crystallizes as colourless
plates from Et20, m.p. 104-5°C and also furnishes a series of crystalline salts
and derivatives.
Chemische Eigenschaften
white powder
Verwenden
A metabolite of Phenmetrazine.
Sicherheitsprofil
A human poison by
ingestion. Poison experimentally by
intravenous, subcutaneous, and
intraperitoneal routes. Moderately toxic by
an unspecified route. Human systemic
effects by ingestion: sleep, increased pulse
rate without blood pressure decrease, and
chronic pulmonary edema or congestion,
convulsions, headache, and blood pressure
elevation. Used in production of drugs of
abuse. When heated to decomposition it
emits toxic fumes of NOx.
Einzelnachweise
Kanao., Ber., 63,95 (1930)
Wolfes., Arch. Pharrn., 268,87 (1930)
Hey., J. Chern. Soc., 1232 (1930)
Akabori, Momotani., J. Chern. Soc., Japan, 64, 608 (1943)
Hoover, Hass., J. Org. Chern., 12,506 (1947)
L-Norephedrin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
