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Norgestimate

Norgestimate Struktur
35189-28-7
CAS-Nr.
35189-28-7
Englisch Name:
Norgestimate
Synonyma:
D-138;orf10131;Norgestimat;Norpregnate;NORGESTIMATE;Norgestimate CRS;NorgestimateUsp27;dexnorgestrelacetime;Norgestimate (200 mg);Norgestimate USP/EP/BP
CBNumber:
CB2110884
Summenformel:
C23H31NO3
Molgewicht:
369.5
MOL-Datei:
35189-28-7.mol

Norgestimate Eigenschaften

Schmelzpunkt:
216°C
alpha 
D25 +110°
Siedepunkt:
497.9±45.0 °C(Predicted)
Dichte
1.22±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
L?slichkeit
DMSO: soluble5mg/mL (clear solution)
Aggregatzustand
powder
pka
12.21±0.60(Predicted)
Farbe
white to beige
Optische Aktivit?t
[α]/D 43±3°, c = 1 in chloroform
BRN 
6440219
Stabilit?t:
Hygroscopic
CAS Datenbank
35189-28-7
EPA chemische Informationen
18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17.alpha.)- (35189-28-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 63-22-36/38-62
S-S?tze: 26-36/37
WGK Germany  3
RTECS-Nr. JF7976000
HS Code  2937230000
Giftige Stoffe Daten 35189-28-7(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Norgestimate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Norgestimate is an orally-effective progestogen, recently launched in combination with ethinyl estradiol as an oral contraceptive.

Chemische Eigenschaften

White Crystalline Solid

Allgemeine Beschreibung

Norgestimate, (17α)-17-acetyloxy-13-ethyl-18,19-dinor-pregn-4-en-20yn-3-one oxime, is a 19-nortestosterone, 3-oxime prodrug that is orally active andused with an estrogen in oral contraceptive products. It hasminimal androgenic action. Norgestimate is metabolized to17-deacetylnorgestimate (norelgestromin) and norgestrel,which provide the progestational action.

Stoffwechsel

Norgestimate is considered to be a pro-proges tin (prodrug), because it rapidly undergoes a two-s tep m etabolic transformation to form two active products, norelgestromine (levonorgestrel 3-oxime) and levonorgestrel. Deacetylation occurs in the intestine and liver, whereas convers ion of the 3-oxime to the corresponding ketone occurs primarily in the liver. Unlike the other progestins mentioned, norgestimate and its metabolites are not bound to SHBG.

Norgestimate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Norgestimate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 155)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58

35189-28-7()Verwandte Suche:


  • 13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl acetate
  • (17R)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime
  • Norgestimate (200 mg)
  • (17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-OxiMe
  • (17a)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-Oxime
  • D-138
  • (17-alpha)-17-(acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one3-oxime
  • 18,19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha
  • 19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha)-1
  • d-13-beta-ethyl-17-alpha-ethynyl-17-beta-acetoxygon-4-en-3-oneoxime
  • dexnorgestrelacetime
  • orf10131
  • NORGESTIMATE
  • Norgestimat
  • NORGESTIMATE, USP STANDARD
  • NorgestimateUsp27
  • acetic acid [(3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] ester
  • Norgestimate for system suitability CRS
  • Norgestimate CRS
  • Norgestimate (Mixture of Z and E Isomers)
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17α)-
  • (8R,9S,10R,12R,14S,17S)-12-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • Norgestimate USP/EP/BP
  • NorgestimateQ: What is Norgestimate Q: What is the CAS Number of Norgestimate Q: What is the storage condition of Norgestimate Q: What are the applications of Norgestimate
  • 35189-28-7 Norgestimate
  • Norgestimate (1471914)
  • 4-ESTREN-17α- ETHYNYL-18-HOMO-17β- OL-3-ONE(-)-ACETATE-OXIME
  • (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • Norpregnate
  • 35189-28-7
  • 25189-28-7
  • C23H31NO3
  • Metabolite Reference Standard
  • Isotopically Labeled Pharmaceutical Reference Standard
  • VAGISTAT
  • Hormone
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
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