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Guaifenesin

Guaifenesin Struktur
93-14-1
CAS-Nr.
93-14-1
Bezeichnung:
Guaifenesin
Englisch Name:
Guaifenesin
Synonyma:
GLYCERYL GUAIACOLATE;GUAIPHENESIN;3-(2-methoxyphenoxy)propane-1,2-diol;gge;XL-90;Robitussin;RAC GUAIFENESIN;Glyceryl guaiacyl ether;GUAIACOL GLYCEROL ETHER;Glyceryl guaiacolate ether
CBNumber:
CB1743199
Summenformel:
C10H14O4
Molgewicht:
198.22
MOL-Datei:
93-14-1.mol

Guaifenesin Eigenschaften

Schmelzpunkt:
77-81 °C
Siedepunkt:
215 °C (19 mmHg)
Dichte
1.1825 (rough estimate)
Brechungsindex
1.5550 (estimate)
Flammpunkt:
215°C/19mm
storage temp. 
2-8°C
L?slichkeit
50g/l (experimental)
pka
13.53±0.20(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserl?slichkeit
5 g/100 mL (25 ºC)
Merck 
14,4555
BRN 
2049375
InChIKey
HSRJKNPTNIJEKV-UHFFFAOYSA-N
LogP
1.390
CAS Datenbank
93-14-1(CAS DataBase Reference)
NIST chemische Informationen
3-(O-methoxyphenoxy)-1,2-propanediol(93-14-1)
EPA chemische Informationen
Guaifenesin (93-14-1)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36/37/38
S-S?tze: 26-36
WGK Germany  1
RTECS-Nr. TY8400000
Hazard Note  Harmful
TSCA  Yes
HS Code  29093090
Giftige Stoffe Daten 93-14-1(Hazardous Substances Data)
Toxizit?t LD50 oral in rabbit: 2553mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Guaifenesin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Guaifenesin is an oral expectorant drug. The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract. It is a common ingredient in prescription and over-the-counter medications used to treat cough due to colds and minor upper respiratory infections. Additionally, Guaifenesin is also a centrally-acting muscle relaxant and is used routinely in combination with analgesics and sedatives in large-animal veterinary surgery.

Chemische Eigenschaften

This substance is a white crystalline powder with a melting point of 78.5-79°C and a boiling point of 215°C (2.53kPa). It is soluble in 20ml of water and ethanol, chloroform, glycerin, and dimethylformamide. It is easily soluble in benzene but insoluble in petroleum ether. It has a slightly bitter taste and a slightly particular odor.

Verwenden

Guaifenesin is a muscle relaxant with expectorant properties often used as an expectorant to facilitate the removal of phlegm from the airways in acute respiratory tract infections. Guaifenesin comes in tablet and capsule form, as syrup, as dissolving granules, and recently as an extended-release (longacting) tablet. The tablets, capsules, dissolving granules, and syrup are usually taken with or without food every 4 h as needed. The extended-release tablet is usually taken with or without food every 12 h.

Allgemeine Beschreibung

Guaifenesin is an expectorant, widely used in the treatment of cough. Its mode of action involves the alleviating of cough discomfort by increasing sputum volume and decreasing its viscosity, thus resulting in effective cough.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Mechanism of action

Guaiphenesin facilitates secretion from bronchial mucous membranes, thus relieving a cough in colds, bronchitis, and bronchial asthma.

Environmental Fate

Guaifenesin’s production and use as veterinary and human medicines may result in its release to the environment through various waste streams.
If released to air, an estimated vapor pressure of 1.5× 10–6 mm Hg at 25 ℃ indicates that guaifenesin will exist in both the vapor and particulate phase.
Based upon an estimated Henry’s law constant of 4.4 × 10-11 atm-m3 mol-1, volatilization from moist soil surfaces or from water surfaces are not expected to be important fate processes for guaifenesin.
Guaifenesin is expected to have high mobility in soil based upon an organic carbon–water partition coefficient (Koc) of 140, which indicates that it will have more solubility in water and is less likely to adsorb onto organic matter in soil and plants.

Einzelnachweise

[1] Peter V. Dicpinigaitis and Yvonne E. Gayle, Effect of Guaifenesin on Cough Reflex Sensitivity, 2003, vol. 124, 2178-2181 DOI:10.1378/CHEST.124.6.2178
[2] Leonid Kagan, Eran Lavy and Ammon Hoffmann, Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model, Pulmonary Pharmacology & Therapeutics, 2009, vol. 22, 260-265 DOI:10.1016/j.pupt.2008.12.020
[3] Sittig's Pharmaceutical Manufacturing Encyclopedia
[4] Synthesis of Essential Drugs (2006, Elsevier)
[5] Plumb's Veterinary Drug Handbook
[6] https://pubchem.ncbi.nlm.nih.gov/compound/Guaifenesin

Guaifenesin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Guaifenesin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 630)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 2994 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12795 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55

93-14-1(Guaifenesin)Verwandte Suche:


  • 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane
  • 1,2-Propanediol, 3-(2-methoxyphenoxy)-
  • 1,2-Propanediol, 3-(o-methoxyphenoxy)-
  • 2/G
  • 2-G
  • 3-(2-Methoxyphenosy)-1,2-propamediol
  • 3-(2-methoxyphenoxy)-2-propanediol
  • 3-(o-methoxyphenoxy)-2-propanediol
  • 3-(o-Methoxyphenoxy)-propanediol-1,2
  • GUAIFENESIN /( )-3-(O-METHOXYPHENOXY)-1,2-PROPANEDIOL
  • 3-(2-Methoxyphenoxy)-1,2-propanediol, erythro + threo, 99+%
  • 3-o-Methoxyphenoxypropane 1:2-diol
  • 3-o-methoxyphenoxypropane1:2-diol
  • Aeronesin
  • alpha-Glyceryl guaiacol ether
  • alpha-Glyceryl guaiacolate ether
  • alpha-glycerylguaiacolateether
  • alpha-glycerylguaiacolether
  • Aresol
  • Breonesin
  • Bronchol
  • Calmipan
  • component of Brondecon
  • component of Colrex Expectorant
  • component of Hycotuss
  • component of Trind
  • component of Trind-DM
  • Cortussin
  • Creson
  • Dilyn
  • Dorassin
  • Flartussin
  • G 87
  • g87
  • Gaiamar
  • Glycerin guaiacolate
  • Glycerin monoguaiacol ether
  • glyceringuaiacolate
  • glycerinmonoguaiacolether
  • glycero-guaiacolether
  • Glycerol alpha-(2-methoxyphenyl) ether
  • Glycerol alpha-(o-methoxyphenyl)ether
  • Glycerol alpha-guaiacyl ether
  • Glycerol alpha-guiacyl ether
  • Glycerol alpha-monoguaiacol ether
  • Glycerol mono(2-methoxyphenyl) ether
  • glycerolalpha-(2-methoxyphenyl)ether
  • glycerolalpha-(o-methoxyphenyl)ether
  • glycerolalpha-guaiacylether
  • glycerol-alpha-guajakolether
  • glycerol-alpha-monoguaiacolether
  • glycerolmono(2-methoxyphenyl)ether
  • Glyceryl guaiacol
  • Glyceryl guaiacol ether
  • Glyceryl guaicolate
  • Glyceryl guiacolate
  • glycerylguaiacol
  • glycerylguaiacolateether
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