2,3-Epoxy-1-propanol
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2,3-Epoxy-1-propanol Eigenschaften
- Schmelzpunkt:
- -54 °C
- Siedepunkt:
- 61-62 °C/15 mmHg (lit.)
- Dichte
- 1.117 g/mL at 25 °C (lit.)
- Dampfdichte
- 2.15 (vs air)
- Dampfdruck
- 0.9 mm Hg ( 25 °C)
- Brechungsindex
- n
20/D 1.433(lit.)
- Flammpunkt:
- 178 °F
- storage temp.
- -20°C
- L?slichkeit
- Soluble in acetone, alcohol, benzene, chloroform, and ether (Weast, 1986)
- pka
- 14.62±0.10(Predicted)
- Aggregatzustand
- Powder, Crystals or Chunks
- Farbe
- White to light yellow-beige
- Wasserl?slichkeit
- soluble
- Merck
- 13,4503
- BRN
- 383562
- Expositionsgrenzwerte
- TLV-TWA 75 mg/m3 (25 ppm) (ACGIH); 150 mg/m3 (50 ppm) (OSHA); IDLH 500 ppm (NIOSH).
- Stabilit?t:
- Stability Stable, but may explode on contact with strong acids, strong bases, heavy metals, heavy metal salts. May decompose on exposure to water or moist air.
- InChIKey
- CTKINSOISVBQLD-UHFFFAOYSA-N
- LogP
- -0.95 at 25℃
- CAS Datenbank
- 556-52-5(CAS DataBase Reference)
- IARC
- 2A (Vol. 77) 2000
- NIST chemische Informationen
- Glycidol(556-52-5)
- EPA chemische Informationen
- Glycidol (556-52-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T | ||
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R-S?tze: | 45-60-21/22-23-36/37/38-68 | ||
S-S?tze: | 53-45-36/37-26 | ||
RIDADR | UN 2810 6.1/PG 3 | ||
OEB | A | ||
OEL | TWA: 25 ppm (75 mg/m3) | ||
WGK Germany | 3 | ||
RTECS-Nr. | UB4375000 | ||
F | 10-21 | ||
Selbstentzündungstemperatur | 780 °F | ||
Hazard Note | Toxic | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29109000 | ||
Giftige Stoffe Daten | 556-52-5(Hazardous Substances Data) | ||
Toxizit?t | Acute oral LD50 for mice 431 mg/kg, rats 420 mg/kg (quoted, RTECS, 1985). | ||
IDLA | 150 ppm |
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Alarmwort | Achtung | |||||||||||||||||||||||||||||||||||||||||||||||||
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Sicherheit |
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2,3-Epoxy-1-propanol Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE LEICHT VISKOSE FLüSSIGKEIT.CHEMISCHE GEFAHREN
Kann polymerisieren Zersetzung bei Kontakt mit starken S?uren und Basen, Metallsalzen oder Metallen unter Feuer- und Explosionsgefahr. Greift Kunststoff und Gummi an.ARBEITSPLATZGRENZWERTE
TLV: 2 ppm (als TWA); Krebskategorie A3 (best?tigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).MAK: Hautresorption; Krebserzeugend Kategorie 2; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation der D?mpfe, über die Haut und durch Verschlucken.INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann schnell eine gesundheitssch?dliche Kontamination der Luft eintreten.WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:Die Substanz reizt die Augen, die Haut und die Atemwege. M?glich sind Auswirkungen auf das Zentralnervensystem. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann Bewusstseinstrübung verursachen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wahrscheinlich krebserzeugend für den Menschen. Tierversuche zeigen, dass die Substanz m?glicherweise fruchtbarkeitssch?digend oder entwicklungssch?digend wirken kann.LECKAGE
Pers?nliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabh?ngigem Atemschutzger?t. Ausgelaufene Flüssigkeit m?glichst in abdichtbaren Glas- oder Weichstahlbeh?ltern sammeln. Reste mit trockenem Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.R-S?tze Betriebsanweisung:
R45:Kann Krebs erzeugen.R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R21/22:Gesundheitssch?dlich bei Berührung mit der Haut und beim Verschlucken.
R23:Giftig beim Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R68:Irreversibler Schaden m?glich.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Glycidol is a chiral molecule with epoxide and primary alcohol functional groups. It is racemic mixture and exists in the dextrorotatory and the levorotatory enantiomeric forms. Several synthetic methods are available for preparation of glycidol. However, it is commercially prepared from the epoxidation of allyl alcohol with hydrogen peroxide and a catalyst (tungsten or vanadium), or from the reaction of epichlorohydrin with caustic. Glycidol has been used in the industrial synthesis of pharmaceutical products since the 1970s. However, its use for research purposes has been reported since 1956. Available information indicates that glycidol is manufactured by several companies in Japan, Germany, and the United States.Chemische Eigenschaften
Glycidol is a colorless liquid.Verwenden
Glycidol is a Stabilizer in the manufacture of vinyl polymers; chemical intermediate in preparation of glycerol, glycidyl ethers, esters, and amines; in pharmaceuticals; in sanitary chemicals.
Definition
an epoxideAllgemeine Beschreibung
Odorless clear colorless liquid.Air & Water Reaktionen
Sensitive to moisture.Reaktivit?t anzeigen
Glycidol is sensitive to moisture. Glycidol is also sensitive to light. Glycidol may polymerize if heated above room temperature. Glycidol may darken on storage. Stability studies of Glycidol stored for two week protected from light indicated definite decomposition at 140° F, and strongly indicated instability at 77° F. A solution of Glycidol in water was found to be unstable when stored at room temperature, even after one day in the dark. Glycidol is incompatible with strong oxidizers. Glycidol will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). Glycidol is also incompatible with nitrates. Glycidol will attack some forms of plastics, rubber and coatings.Hazard
Toxic material. Probable carcinogen.Health Hazard
Glycidol is an eye, lung, and skin irri-tant. The pure compound caused severebut reversible corneal injury in rabbit eyes(ACGIH 1986). Exposure to its vapor causedirritation of lung in mice, resulting in pneu-monitis. There is no evidence of any cumula-tive toxicity. From the limited toxicity data,it appears that the health hazard to humansfrom its exposure is, primarily, respiratoryirritation, stimulation of the central nervoussystem, and depression.Glycidol is mutagenic, testing positive inthe histidine reversion–Ames test. There isno report of its carcinogenic action. Oraland intraperitoneal administration of gly-cidol in rats showed harmful effects onfertility.
Brandgefahr
Glycidol is combustible.Sicherheitsprofil
Confirmed carcinogen with carcinogenic data reported. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and sh contact. Experimental teratogenic and reproductive effects. A skin irritant. Human mutation data reported. Animal experiments suggest somewhat lower toxicity than for related epoxy compounds. Readdy absorbed through the skin. Causes nervous excitation followed by depression. Explodes when heated or in the presence of strong acids,bases, metals (e.g., copper, zinc), and metal salts (e.g., aluminum chloride, iron(II1) chloride, tin(Iy chloride). When heated to decomposition it emits acrid smoke and fumes. See also DIGLYCIDYL ETHER.Synthese
A method for directly preparing glycidol from glycerol is shown as following steps: putting a mixed solvent in a glass or enamel reaction kettle, adding glycerol to the mixed solvent, controlling the concentration of glycerol in the reaction liquid within the range of 0.5-3.0 mol/L, then adding a catalyst, and controlling the quantity of the catalyst to account for 0.01-0.20 of the weight of the glycerol; increasing the temperature of the mixed reaction liquid to the range of 40-100 ℃ under stirring condition and reacting at a constant temperature for 2-20 hours; and after reaction, filtering off the catalyst from the reaction liquid, then distilling the mixed reaction liquid, and collecting the fraction in the range of 160-161 ℃, thereby obtaining the product 2,3-glycidol.m?gliche Exposition
Glycidol is used as an intermediate in the synthesis of glycerol, glycidyl ethers, esters, and amines.Carcinogenicity
Glycidol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.Environmental Fate
Chemical/Physical. May hydrolyze in water forming glycerin (Lyman et al., 1982).Versand/Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.l?uterung methode
[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.Inkompatibilit?ten
May form explosive mixture with air. Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts, e.g., alu minum chloride, ferric chloride, and tin chloride), or metals (copper and zinc), causing fire and explosion hazard. Contact with barium, lithium, sodium, magnesium, and tita nium may cause polymerization. Attacks some plastics, rubber, and coatings.Waste disposal
Concentrated waste contain ing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.2,3-Epoxy-1-propanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Dihydrogenwolframat
(+/-)-1-GLYCEROL POLYSTYRENE
Wasserstoffperoxid
Peroxyessigs?ure ...%
Glycerinacetat
Propan-1,2-diol
Allylalkoholl
1-Chlor-2,3-epoxypropan
Downstream Produkte
2,3-Epoxy-1-propanol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 317)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 |
allison@yan-xi.com | China | 5857 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5889 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1015 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 861 | 58 |
Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 |
admin@hblongbang.com | China | 941 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 939 | 58 |
Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 |
niki@zlchemi.com | China | 3001 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29793 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
556-52-5(2,3-Epoxy-1-propanol)Verwandte Suche:
1-Allyloxy-2,3-epoxy-propan
1,2-Epoxypropan
Phenolic epoxy resin
Propan-1-ol
Propan-2-ol
Oxiran-2-carboxamid
1-Chlor-2,3-epoxypropan
Ethylenoxid
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Titantetraisopropanolat
Titan(4+)ethanolat
Tetraethylmethylenbisphosphonat
2,3-Epoxypropylacrylat
2,3-Epoxypropylmethacrylat
1,2,3,4-Diepoxybutan
1,2-Epoxy-3-phenoxypropan
EPOXY
Allylalkoholl
- (+/-)-GLYCIDOL
- GLYCIDOL
- 3-HYDROXYPROPYLENE OXIDE
- 2,3-EPOXYPROPAN-1-OL
- 2,3-EPOXYPROPANOL-1
- (+/-)-OXIRANE-2-METHANOL
- (±)-Oxiranyl-methanol
- 2-hydroxymethyloxiran
- 2-Oxiranylmethanol
- (RS)-Glycidol
- ±-Oxiranyl-methanol
- 1,2-Epoxy-3-hydroxypropane
- 1-Hydroxy-2,3-epoxypropane
- 1-Propanol, 2,3-epoxy-
- 1-Propanol,2,3-epoxy-
- 2-(Hydroxymethyl)oxirane
- 2,3-epoxy-1-propano
- 2,3-Epoxyproqanol
- rac-(R*)-Oxirane-2-methanol
- rac-Oxirane-2α*-methanol
- Glycidol ,97%
- 3-Hydroxy-1,2-propenoxide
- lycidol
- Glycidol, 2,3-Epoxypropan-1-ol, 2-(Hydroxymethyl)oxirane, Epihydrin alcohol
- Glycidol, 96% 100ML
- Glycidol, 96% 500ML
- 3-Hydroxy-1,2-Propenoxide/Glycidol
- [3-(hydroxyMethyl)oxiran-2-yl](oxiran-2-yl)Methanol
- Glycidol 96%
- Glycidol, 2,3-Epoxypropan-1-ol, Epihydrin alcohol, 3-Hydroxy-1,2-propenoxide
- 3-Hydroxypropenoxid
- Allyl alcohol oxide
- allylalcoholoxide
- dl-Glycidol
- Epihydrin alcohol
- epihydrinalcohol
- EpiolOH
- Epoxypropyl alcohol
- epoxypropylalcohol
- Glyceringlycid
- Glycide
- glycidylalcohol
- Hydroxymethyl ethylene oxide
- hydroxymethylethyleneoxide
- Hydroxymethyloxiran
- Hydroxymethyloxirane
- Methanol, oxiranyl-
- Monoepoxide glycidol
- NCI-C55549
- Oxiranemethanol,(±)-
- Oxiranmethanol
- oxiranyl-methano
- Oxiranylmethanol
- Racemicglycidol
- 2,3-Epoxy-1-propanol (Glycidol)
- 2 3-EPOXY-1-PROPANOL 97% (GC)
- Glycidol96%
- (2S)-Oxirane-2-methanol