4-Hydroxy-α-[(methylamino)methyl]benzylalkoholhydrochlorid
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- CAS-Nr.
- 5985-28-4
- Bezeichnung:
- 4-Hydroxy-α-[(methylamino)methyl]benzylalkoholhydrochlorid
- Englisch Name:
- Synephrine hydrochloride
- Synonyma:
- SYNEPHRINE HCL;JACS-5985-28-4;UNII-EN5D1IH09S;Synephrine HCl 98%min;N-METHYL OCTOPAMINE HCL;Sympathol hydrochloride;Synephrine hydrochlorid;SYNEPHRINE HYDROCHLORIDE;Synephrine/Synephrine Hcl;(±)-Oxedrine hydrochloride
- CBNumber:
- CB1690109
- Summenformel:
- C9H14ClNO2
- Molgewicht:
- 203.67
- MOL-Datei:
- 5985-28-4.mol
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4-Hydroxy-α-[(methylamino)methyl]benzylalkoholhydrochlorid Eigenschaften
- Schmelzpunkt:
- 147-150°C
- storage temp.
- Refrigerator
- L?slichkeit
- Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Pale Beige
- InChI
- InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
- InChIKey
- COTCEGYSNTWJQV-UHFFFAOYSA-N
- SMILES
- C1(=CC=C(O)C=C1)C(O)CNC.Cl
- LogP
- -0.030 (est)
- CAS Datenbank
- 5985-28-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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4-Hydroxy-α-[(methylamino)methyl]benzylalkoholhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α
1A-, α
2A-, and α
2C-adrenergic receptors (ARs; K
is = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α
1A-ARs in HEK293 cells (EC
50 = 4 μM in a reporter assay) but not in CHO cells expressing α
2A- or α
2C-AR. It also acts as an antagonist of α
1A-, α
2A-, and α
2C-ARs, inhibiting L-phenylephrine-induced activation of α
1A-AR in HEK293 cells and activation of α
2A- and α
2C-ARs induced by the α
2-AR agonist medetomidine in CHO cells (IC
50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC
50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
Chemische Eigenschaften
Pale Beige Solid
Verwenden
A α-adrenergic receptor agonist, vasoconstrictor.
4-Hydroxy-α-[(methylamino)methyl]benzylalkoholhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Hydroxy-α-[(methylamino)methyl]benzylalkoholhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 362)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
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Chengdu ChenLv Herb Co.,Ltd
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+86-13608205856; +undefined13608205856
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maryextract@126.com |
China |
127 |
58 |
|
Hebei Weibang Biotechnology Co., Ltd
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+8615531157085
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abby@weibangbio.com |
China |
8806 |
58 |
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Hebei Mujin Biotechnology Co.,Ltd
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+86 13288715578 +8613288715578
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sales@hbmojin.com |
China |
12831 |
58 |
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Hebei Yanxi Chemical Co., Ltd.
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+8617531153977
|
allison@yan-xi.com |
China |
5856 |
58 |
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Hebei Chuanghai Biotechnology Co,.LTD
|
+86-13131129325
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sales1@chuanghaibio.com |
China |
5889 |
58 |
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Xiamen Wonderful Bio Technology Co., Ltd.
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+8613043004613
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Sara@xmwonderfulbio.com |
China |
283 |
58 |
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Shaanxi Haibo Biotechnology Co., Ltd
|
+undefined18602966907
|
qinhe02@xaltbio.com |
China |
997 |
58 |
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Shaanxi TNJONE Pharmaceutical Co., Ltd
|
+8618092446649
|
sarah@tnjone.com |
China |
1143 |
58 |
|
BINBO BIOLOGICAL CO.,LTD
|
+8618629063126
|
info@binbobiological.com |
China |
430 |
58 |
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
+8613343047651
|
admin@zlchemi.com |
China |
3692 |
58 |
5985-28-4(4-Hydroxy-α-[(methylamino)methyl]benzylalkoholhydrochlorid)Verwandte Suche:
- 1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride
- 4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride
- l-1-p-hydroxyphenyl-2-methylamino-1-ethanolhydrochloride
- p-hydroxy-alpha-((methylamino)methyl)-benzylalcohohydrochloride
- p-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride
- p-methylaminoaethanolphenolhydrochlorid
- SYNEPHRINE HCL
- SYNEPHRINE HYDROCHLORIDE
- N-METHYL OCTOPAMINE HCL
- p-methylaminoethanolphenolhydrochloride
- 4-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol hydrochloride
- SYNEPHRINE HYDROCHLORIDE 98.0%MIN
- (±)-Oxedrine hydrochloride
- (±)-p-Hydroxynorephedrine hydrochloride
- dl-p-Hydroxynorephedrine hydrochloride
- Sympathol hydrochloride
- Benzenemethanol, 4-Hydroxy-α-((methylamino)methyl)-,hydrochloride
- p-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride
- UNII-EN5D1IH09S
- 4-Hydroxy-α-[(MethylaMino)Methyl]benzeneMethanol Hydrochloride
- rac-Synephrine Hydrochloride
- SYNEPHRINE HYDROCHLORIDE; OXEDRINE HYDROCHLORIDE
- (+)p-synephrine hydrochloride
- 4-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol hyd
- p-Methylaminoaethanolphenol hydrochlorid [German]
- [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methylammonium chloride
- [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methyl-ammonium chloride
- [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methylazanium chloride
- [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methyl-azanium chloride
- 4-[1-hydroxy-2-(methylamino)ethyl]phenol 2,3-dihydroxysuccinate (salt)
- 4-[1-hydroxy-2-(MethylaMino)ethyl]phenol hydrochloride
- Supply High Quality Synephrine hydrochloride powder CAS NO.:5985-28-4 CAS NO.5985-28-4
- Synephrine/Synephrine Hcl
- JACS-5985-28-4
- Synephrine hydrochloride, 98%, an α-adrenergic and -adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids
- Benzenemethanol, 4-hydroxy-a-[(methylamino)methyl]-, hydrochloride
- top quality Synephrine hydrochloride
- Synephrine hydrochloride USP/EP/BP
- Synephrine hydrochlorid
- Pharmaceutical Intermediate CAS?5985-28-4?Synephrine Hydrochloride Synephrine HCl
- Synephrine HCl 98%min
- Synephrine hydrochloride, 10 mM in DMSO
- 5985-28-4
- 227-804-6
- 8985-28-4
- 5983-28-4
- 85-28-4
- 5984-28-4
- C9H14NO2Cl
- Amines
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 5985-28-4
