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Meglutol

3-HYDROXY-3-METHYLGLUTARIC ACID Struktur
503-49-1
CAS-Nr.
503-49-1
Bezeichnung:
Meglutol
Englisch Name:
3-HYDROXY-3-METHYLGLUTARIC ACID
Synonyma:
Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1
CBNumber:
CB1454369
Summenformel:
C6H10O5
Molgewicht:
162.14
MOL-Datei:
503-49-1.mol

Meglutol Eigenschaften

Schmelzpunkt:
105-108 °C (lit.)
Siedepunkt:
120 °C / 13mmHg
Dichte
1.2132 (rough estimate)
Brechungsindex
1.4230 (estimate)
storage temp. 
-20°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
Aggregatzustand
powder to crystal
pka
3.95±0.10(Predicted)
Farbe
White to Light yellow
Merck 
14,5808
BRN 
1769194
CAS Datenbank
503-49-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 22-24/25-36-26
WGK Germany  2
RTECS-Nr. MA3753000
10
HS Code  29181990
Toxizit?t LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Meglutol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.

Chemische Eigenschaften

White Solid

Verwenden

antihyperlipoproteinemia

Definition

ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.

l?uterung methode

Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]

Meglutol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Meglutol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 122)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32002 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 23325 58
Henan Alfa Chemical Co., Ltd
+86-18339805032; +8618339805032
alfa4@alfachem.cn China 13227 58
VladaChem GmbH
+49-7246-3082843
info@vladachem.de Germany 1859 58
Nanjing Doge Biomedical Technology Co., Ltd
+86-25-58227606 +86-15305155328
sales@dogechemical.com China 4128 58

503-49-1(Meglutol)Verwandte Suche:


  • hmga
  • medroglutaricacid
  • 3-HYDROXY-3-METHYLPENTANEDIOIC ACID (HMG)
  • 3-Hydroxy-3-methylglutaric acid ,98%
  • 3-Hydroxy-3-Methylglutaric acid >=95%
  • 3-HYDROXY-3-METHYLGLUTARIC ACID
  • AKOS 91366
  • B-METHYL-B-HYDROXYGLUTARIC ACID
  • B-HYDROXY-B-METHYLGLUTARIC ACID
  • 3-hydroxy-3-methyl-glutaricaci
  • beta-hydroxy-beta-methylglutaricacid
  • cb-337
  • 3-Hydroxy-3-methylglutaricAcid>
  • 3-HYDROXY-3-METHYLPENTANE-1
  • Pentanedioic acid, 3-hydroxy-3-methyl-
  • 3-HYDROXY-3-METHYLGLUTARIC ACID USP/EP/BP
  • 3-Hydroxy-3-methylpentanedioic acid[Dicrotalic Acid
  • 3-Hydroxy-3-methyl-pentanedioic acid, 98+%
  • lipoglutaren
  • 3-Hydroxymethylglutaric acid
  • Meglutol
  • 3-HYDROXY-3-METHYLPENTANEDIOIC ACID
  • DICROTALIC ACID
  • Autophagy,inhibit,Meglutol,Endogenous Metabolite,Inhibitor,HMG-CoA Reductase (HMGCR)
  • Adipic acid impurity3(Meglutto)
  • 503-49-1
  • 1461426
  • HOCCH3CH2CO2H2
  • Organic Building Blocks
  • C6
  • Carboxylic Acids
  • Carbonyl Compounds
  • Building Blocks
  • Miscellaneous Reagents
  • Building Blocks
  • C6
  • Carbonyl Compounds
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • Pharmaceutical Raw Materials
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