ITF2357
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- CAS-Nr.
- 732302-99-7
- Englisch Name:
- ITF2357
- Synonyma:
- ITF2357;CS-1443;ITF2357 (Givinostat);Givinostat(HCl hydrate);Givinostat Hydrochloride Hydrate;Givinostat (ITF2357) 732302-99-7;ITF2357 hydrochloride monohydrate;Givinostat (ITF2357) HCl monohydrate;Gavinostat hydrochloride monohydrate;Givinostat HCl monohydrate (ITF-2357
- CBNumber:
- CB12561481
- Summenformel:
- C24H30ClN3O5
- Molgewicht:
- 475.9651
- MOL-Datei:
- 732302-99-7.mol
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ITF2357 Eigenschaften
- storage temp.
- -20°C
- L?slichkeit
- ≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
- Aggregatzustand
- powder
- Farbe
- white to beige
- CAS Datenbank
- 732302-99-7
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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ITF2357 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Givinostat Hydrochloride Hydrate is a potent inhibitor of HDAC with IC50?of 7.5-16 nM. It is used in the treatment of muscular dystrophy.
Biochem/physiol Actions
Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas).
ITF2357 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ITF2357 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 108)Lieferanten
- (6-((diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate hydrochloride hydrate
- ITF2357
- ITF2357 (Givinostat)
- N-[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride hydrate
- Givinostat (hydrochloride monohydrate)
- Givinostat Hydrochloride Hydrate
- Givinostat (ITF2357) HCl monohydrate
- Givinostat(HCl hydrate)
- CS-1443
- Givinostat (ITF2357) hydrochloride monohydrate
- ITF2357 hydrochloride monohydrate
- Gavinostat hydrochloride monohydrate
- Givinostat HCl monohydrate (ITF-2357
- ITF2357 ITF-2357 Givinostat hydrochloride monohydrate
- Givinostat (ITF2357) 732302-99-7
- Givinostat hydrochloride,ITF-2357 hydrochloride,Givinostat hydrochloride monohydrate,inhibit,HDAC,Histone deacetylases,Inhibitor
- 6-[(Diethylamino)methyl]-2-naphthyl]methyl [4-(Hydroxycarbamoyl)phenyl]carbamate Hydrochloride Hydrate
- Givinostat hydrochloride monohydrate, 10 mM in DMSO
- 732302-99-7
- C24H27N3O4HClH2O
- Inhibitor
- Inhibitors
