3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
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- CAS-Nr.
- 350997-39-6
- Englisch Name:
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- Synonyma:
- OGG1-IN-08;OGG1-IN-O8;O8 OGG1 Inhibitor;OGG1 Inhibitor O8;OGG1 Inhibitor O8 >=98% (HPLC);3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide;3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE;Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide;Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- CBNumber:
- CB11499417
- Summenformel:
- C9H6Cl2N2OS
- Molgewicht:
- 261.13
- MOL-Datei:
- 350997-39-6.mol
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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Eigenschaften
- Dichte
- 1.587±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMF: 5mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
- Aggregatzustand
- powder
- pka
- 11.75±0.30(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
O8 OGG1 Inhibitor is potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
Allgemeine Beschreibung
Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.
Biochem/physiol Actions
OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 40)Lieferanten
350997-39-6()Verwandte Suche:
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- OGG1 Inhibitor O8
- O8 OGG1 Inhibitor
- 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
- OGG1-IN-O8
- OGG1 Inhibitor O8 >=98% (HPLC)
- OGG1-IN-08
- Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide
- 350997-39-6
