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Deslorelin

Deslorelin Struktur
57773-65-6
CAS-Nr.
57773-65-6
Englisch Name:
Deslorelin
Synonyma:
H 4065;tryptal;somagard;Deslelin;DESORELIN;DESLORELIN;bachem9022;Deslorenlin;Deslelin Acetate;DESLORELIN, >99%
CBNumber:
CB1144228
Summenformel:
C64H83N17O12
Molgewicht:
1282.48
MOL-Datei:
57773-65-6.mol

Deslorelin Eigenschaften

Schmelzpunkt:
>189oC
alpha 
D24 -61° (c = 0.37 in 0.1M acetic acid)
Dichte
1.48±0.1 g/cm3(Predicted)
storage temp. 
−20°C
L?slichkeit
Acetic acid (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
9.82±0.15(Predicted)
Farbe
White to Off-White
Sequenz
Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt
InChIKey
GJKXGJCSJWBJEZ-QCOVUDKBNA-N
CAS Datenbank
57773-65-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 60
S-S?tze: 53-22-36/37/39-45
WGK Germany  3
RTECS-Nr. OK6755000
HS Code  3504009000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

Deslorelin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Deslorelin is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production.

Chemische Eigenschaften

White powder, tens of times more biologically active than natural LH-RH, is synthesized by solid-phase or liquid-phase synthesis method using the corresponding protected amino acid monomers as raw materials.

Verwenden

Induction of ovulation in estrous mares Reproduction control in dogs

Trademarks

Somagard [as acetate] (Roberts Pharmaceutical).

Nebenwirkungen

The most common side effects include swelling, sensitivity, and redness or warmth at the injection site. Rarely reported side effects in dogs include prolonged estrus and uterine infections.

Veterinary Drugs and Treatments

Deslorelin is approved for inducing ovulation in estrual mares. There is also interest in developing dosages and dosage forms as a long-term, reversible contraceptive in a variety of animal species, as a treatment for prostatic disease in male dogs, and incontinence in ovariectomized dogs. At the time of writing, deslorelin in not available in the USA, but is marketed in Canada.
In humans, deslorelin has been investigated for treating children with precocious puberty, and in adults for prostate carcinoma, dysmenorrhea, fibroids, and endometriosis.

Einzelnachweise

[1] CLAIRE GROSSET. Contraceptive effect and potential side-effects of deslorelin acetate implants in rats (Rattus norvegicus): preliminary observations.[J]. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2012, 76 3: 209-214.
[2] STEFANO ROMAGNOLI. Chronic Use of Deslorelin in Dogs: Six Cases (2005-2022).[J]. Animals, 2023, 13 2. DOI:10.3390/ani13020265.
[3] K E OERTER. Adult height in precocious puberty after long-term treatment with deslorelin.[J]. Journal of Clinical Endocrinology & Metabolism, 1991, 73 6: 1235-1240. DOI:10.1210/jcem-73-6-1235.

Deslorelin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Deslorelin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 281)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
qingdao future trading Co., Ltd
+86-13335044410 +86-13335044410
cui56813@163.com China 110 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599
info@molchanges.com China 5223 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Shanghai Yunao International Trade Co., Ltd
+8617621705551
asdf@shanghaihg.cn China 264 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Shandong Huisheng Import & Export Co., Ltd.
+86-13176845580 +86-13176845580
da@zhongda-biotech.com China 232 58

57773-65-6()Verwandte Suche:


  • Deslorelin,Deslorelin acetate
  • GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET
  • [D-TRP6, DES-GLY10]-LH-RH ETHYLAMIDE
  • DESORELIN
  • DESLORELIN
  • deslorelin acetate
  • DESLORELIN (HUMAN)
  • DES-GLY10,[D-TRP6]-LH-RH ETHYLAMIDE
  • (DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • (DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (SEA BREAM)
  • (DES-GLY10,D-TRP6,PRO-NHET9)-LHRH
  • [DES-GLY10, D-TRP6, PRO-NHET9]-LH-RH (HUMAN)
  • (DES-GLY10,D-TRP6,PRO-NHET9)-LHRH (SEA BREAM)
  • (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (SEA BREAM)
  • (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • [DES-GLY10, D-TRP6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN
  • (DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE (SEA BREAM)
  • des-gly10,(D-trp6)luteinizing hormone*releasing H
  • DES-GLY10,(D-TRP6)LUTEINIZING HORMONE*RE LEASING HOR
  • 1-9-Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-9-(N-ethyl-L-prolinamide)-
  • PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO NHCH2CH3
  • PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NH-ETHYL
  • PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET
  • PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET
  • luteinizinghormone-releasingfactor(pig),6-d-tryptophan-9-(n-ethyl-l-prolina
  • mide)-10-deglycinamide-
  • somagard
  • tryptal
  • (Des-Gly10,D-Trp6,Proethylamide9)-LRF
  • luteinizing hormone releasing hormone (D-Trp^<6^>) analog
  • Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt acetate salt
  • Delorelin acetate
  • (d-trp(sub6)-pro(sup9)-net)-gnrh
  • (d-trp(sub6)-pro(sup9)-net)-gonadotropinreleasinghormone
  • (d-trp(sup6)-pro(sup9))-lhrhethylamide
  • (d-trp(sup6)-pro(sup9))-luteinizinghormone-releasinghormoneethylamide
  • (d-trp(sup6)-pro(sup9)-net)-gonadotropinreleasinghormon
  • bachem9022
  • d-trp(sup6)-pro(sup9)-n-ethylamide-lhrh
  • (Des-Gly10,D-Trp6,Pro-NHEt9)-LHRH High acetate salt Deslorelin High acetate salt
  • Deslorelin High acetate salt
  • Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt High acetate salt
  • Deslorenlin
  • Deslelin Acetate
  • H 4065
  • DESLORELIN, >99%
  • Deslorelin,H 4065, >99%
  • Deslorelin Acetate / Deslorelin
  • Deslorelin impurity
  • Injectable Lyophillzed Powder Peptides Peptide Deslorelin CAS 57773-65-6
  • To los gonadorelin
  • Deslorelin USP/EP/BP
  • Deslorelin,H 4065
  • Deslelin
  • Deslorelin Acetate(net)
  • Deserelin acetate
  • 57773-65-6
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