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Curcumol

Curcumol Struktur
4871-97-0
CAS-Nr.
4871-97-0
Englisch Name:
Curcumol
Synonyma:
Curcumo;CURCUMOL;Curcumae;Curcumol-RM;(-)-Curcumol;(?)-Curcumol;Curcumol USP/EP/BP;5,8-Epoxy-10(14)-guaien-8-ol;(3S,3aS,5S,6R,8aS)-5-Isopropyl-3-methyl-8-methyleneoctahydro-6H-3a,6-epoxyazulen-6-ol;(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol
CBNumber:
CB0701727
Summenformel:
C15H24O2
Molgewicht:
236.35
MOL-Datei:
4871-97-0.mol

Curcumol Eigenschaften

Schmelzpunkt:
141.0 to 145.0 °C
Siedepunkt:
334.5±42.0 °C(Predicted)
Dichte
1.06±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
L?slichkeit
DMSO:55.67(Max Conc. mg/mL);235.54(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);84.62(Max Conc. mM)
Ethanol:28.5(Max Conc. mg/mL);120.58(Max Conc. mM)
pka
13.02±0.60(Predicted)
Aggregatzustand
Solid
Farbe
White to Light yellow
InChI
InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1
InChIKey
QRMPRVXWPCLVNI-YYFQZIEXSA-N
SMILES
C1[C@]2([H])[C@@]3(O[C@](O)(CC2=C)[C@H](C(C)C)C3)[C@@H](C)C1
LogP
3.276 (est)
CAS Datenbank
4871-97-0

Sicherheit

WGK Germany  3
HS Code  29321900

Curcumol Chemische Eigenschaften,Einsatz,Produktion Methoden

Pharmakokinetik

Curcumol is rapidly absorbed and eliminated in rats following oral administration of 10, 40 and 80 mg/kg curcumol. Its oral and intravenous bioavailability ranges from 9.2% ~ 13.1%. Maximum concentration is reached within 0.5-1.0 hours. In addition, high protein binding of curcumin was observed in rat plasma, ranging from 85.6% to 93.4%.

Einzelnachweise

[1] Wei Wei. “Curcumol: From Plant Roots to Cancer Roots.” International Journal of Biological Sciences 27 1 (2019): 1600–1609.
[2] Ying Liu. “Curcumol ameliorates neuroinflammation after cerebral ischemia-reperfusion injury via affecting microglial polarization and Treg/Th17 balance through Nrf2/HO-1 and NF-κB signaling.” Cell Death Discovery 10 1 (2024): 300.

Curcumol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Curcumol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 259)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
DSHare Pharmaceutical Science Technology Co.Ltd.
+8613962878782
 wei.zhu@dshare.com.cn China 42 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038
zheyansh@163.com CHINA 3619 58
Chengdu Greenpure Biopharma CO.,Ltd 		18283602253; +8618283602253
 jancyzheng@gcgreenpure.com China 953 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29863 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897
 sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Shanghai Standard Technology Co., Ltd. 		18502101150
ft-sales@nature-standard.com CHINA 1923 58
Kindchem(Nanjing)Co.,Ltd 		+86-025-025-85281586 +8618651653755
 sales@kindchem.cn China 1226 58

4871-97-0()Verwandte Suche:

  • 6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,3aS,5S,6R,8aS)-
  • (3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol
  • CURCUMOL
  • (3s-(3a,3aa,5a,6a,8ab))-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6h-3a,6-epoxyazulen-6-ol
  • 5,8-Epoxy-10(14)-guaien-8-ol
  • (3S-(3alpha,3Aalpha,5alpha,6alpha,8abeta))-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3A,6-epoxyazulen-6-ol
  • Curcumae
  • Curcumol USP/EP/BP
  • Curcumo
  • (-)-Curcumol
  • (3S,3aS,5S,6R,8aS)-5-Isopropyl-3-methyl-8-methyleneoctahydro-6H-3a,6-epoxyazulen-6-ol
  • Curcumol-RM
  • (?)-Curcumol
  • 4871-97-0
  • chemical reagent
  • Inhibitors
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products
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