Pioglitazone hydrochloride
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- CAS-Nr.
- 112529-15-4
- Englisch Name:
- Pioglitazone hydrochloride
- Synonyma:
- PIOGLITAZONE HCL;ACTOS;Piog;PiogL;AD-4833;U-72107E;U-72107A;itazone HydrochL;$350/50G,99%,IN STOCK;Pioglitazone Hydro...
- CBNumber:
- CB0411844
- Summenformel:
- C19H21ClN2O3S
- Molgewicht:
- 392.9
- MOL-Datei:
- 112529-15-4.mol
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Pioglitazone hydrochloride Eigenschaften
- Schmelzpunkt:
- 193-194°C
- RTECS-Nr.
- XJ5813440
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Wasserl?slichkeit
- Soluble in water (<1 mg/ml at 25°C), DMF, methanol, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C).
- Merck
- 14,7452
- BCS Class
- 2
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey
- GHUUBYQTCDQWRA-UHFFFAOYSA-N
- CAS Datenbank
- 112529-15-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/38-36 |
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| S-S?tze: |
22-24/25-26 |
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| WGK Germany |
3 |
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| HazardClass |
IRRITANT |
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| HS Code |
29341000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Pioglitazone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insulin dependent diabetes mellitus
(NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester
into thiazolidine with thiourea. As with other representatives in this
class, it potently activates the nuclear receptor peroxisome proliferator-activated
receptor gamma which is believed to be involved in the regulation of insulin
resistance and adipogenesis. In several obese and obese diabetic animal
models, treatment with Pioglitazone resulted in reductions in plasma glucose
and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insulin, was shown
to significantly improve glycemic control in type-2 diabetes and demonstrated a
beneficial effect on insulin resistance and other clinically relevant parameters as
plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be
safe and well tolerated and is said to have a lower occurrence of hepatic toxicity
as well as a low probability for drug interaction.
Chemische Eigenschaften
Colourless Prisms
Verwenden
Pioglitazone hydrochloride is a euglycemic agent,used as an antidiabetic.
Allgemeine Beschreibung
Pioglitazone hydrochloride is an oral antidiabetic agent used in the treatment of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes.
Pioglitazone hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pioglitazone hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 696)Lieferanten
112529-15-4()Verwandte Suche:
- 5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzylidine]-2,4-thiazolidinedionehydrochloride
- AD-4833
- pioglitazone hydrochioride
- Pioditazone hydrochloride
- PIODLITAZONE HYDROCHLORIC
- 5-{4-[2-(5-ETHYL-PYRIDIN-2-YL)-ETHOXY]-BENZYL}-THIAZOLIDINE-2,4-DIONE HCL
- 5-{4-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-benzyl}-
- 5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride
- 5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride
- Pioglitazone Hydrochloride (50 mg)
- (5R)-5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}Methyl)-1,3-thiazolidine-2,4-dione
- Effects of pioglitazone
- 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione Hydrochloride
- [5-[[4-[2-(5-ETHYL-PYRIDIN-2-YL)ETHOXY]PHENYL]METHYL]-2,4-] THIAZOLIDINEDIONE HCL
- (R)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride
- 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride
- Pioglitazone for system suitability
- 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione,hydrochloride (1:1)
- U-72107E
- Pioglitazone hydrochloride, >=99%
- thiazolidinedione hydrochloride
- 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride
- U-72107A
- 5-((4-(2-(5-ETHYL-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-2,4-THIAZOLIDINEDIONE, HCL
- [5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidinedione hydrochloride
- PIOGLITAZONE HYDROCHLORIDE
- (RS)-5-(4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl)thiazolidine-2,4-dione hydrochloride
- Pioglitazone hydrochloride, 99%, a receptor-gamma (PPARgamma) agonist
- (+-5-[[4-[2-(5-ETHYL-2-PYRIDINYL)ETHOXY] PHENYL]METHYL]-2 4-] THIAZOLIDINEDIONE H YDROCHLORIDE(PIOGLITAZONE HCL)
- Pioglitazone hydrochloride, 99%, receptor-gamma (PPARgamma) agonist
- $350/50G,99%,IN STOCK
- Pioglitazone hydrochloride SALT
- Pioglitazone for system suitability CRS
- Pioglitazone hydrochloride CRS
- PioglitazoneHydrochloride>
- Pioglitazone Hydrochloride RS
- itazone HydrochL
- Piog
- Pioglitazone hydrochloride Solution in Methanol, 100μg/mL
- PiogL
- Pioglitazone hydrochloride USP/EP/BP
- Pioglitazone hydrochloride5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]Methyl]-2,4-thiazolidinedionehydrochloride
- Pioglitazone HydrochlorideQ: What is
Pioglitazone Hydrochloride Q: What is the CAS Number of
Pioglitazone Hydrochloride Q: What is the storage condition of
Pioglitazone Hydrochloride Q: What are the applications of
Pioglitazone Hydrochloride
- Pioglitazone hydrochloride, 98%,
- Pioglitazone Hydrochloride (1539905)
- ACTOS
- PIOGLITAZONE HCL
- Pioglitazone hydrochloride
(RS)-5-(4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl)thiazolidine-2,4- dione hydrochloride
- Pioglitazone Hydro...
- C16216000 PioglitazonEHydrochloride
- Pioglitazone hydrochloride, PPAR-gamma agonist
- 112529-15-4
- 12529-15-4
- C19H20N2O3SHCl
- C19H20N2O3SxHCl
- C20H21N2O3S
- C19H21N2O3ClS
- C19H20N2O3SClH
