5-α-Pregnan-3,20-dion
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- CAS-Nr.
- 566-65-4
- Bezeichnung:
- 5-α-Pregnan-3,20-dion
- Englisch Name:
- 5α-Pregnane-3,20-dione
- Synonyma:
- Pregnane-3,20-dione;5α-dihydroprogesterone;5α-Dihydroprogesterone;5α-pregnane-3,20-dione;ALLOPREGNANDIONE;Allopregnanedione;Pregnane-3,20-dlone;Estrone Impurity 23;5A-PREGNAN-3,20-DIONE;5A-DIHYDROPROGESTERONE
- CBNumber:
- CB0377209
- Summenformel:
- C21H32O2
- Molgewicht:
- 316.48
- MOL-Datei:
- 566-65-4.mol
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5-α-Pregnan-3,20-dion Eigenschaften
- Schmelzpunkt:
- 200 °C
- Siedepunkt:
- 429.2±38.0 °C(Predicted)
- Dichte
- 1.048±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14?,16-,17+,18-,19-,20-,21+/m0/s1
- InChIKey
- XMRPGKVKISIQBV-CVHNGYJVSA-N
- SMILES
- C1(=O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)C)CC3)CC2
- CAS Datenbank
- 566-65-4(CAS DataBase Reference)
- NIST chemische Informationen
- 3,20-Allopregnanedione(566-65-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
WGK Germany |
3 |
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RTECS-Nr. |
TU4157150 |
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HS Code |
2937.29.9095 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P280,P302+P352, P312, P322, P363,P501 |
H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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Sicherheit |
P201 |
Vor Gebrauch besondere Anweisungen einholen. |
P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
P322 |
Gezielte Ma?nahmen |
P330 |
Mund ausspülen. |
P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
P405 |
Unter Verschluss aufbewahren. |
P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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5-α-Pregnan-3,20-dion Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(5α)-Pregnane-3,20-dione exerts neuroprotective effects in chronic autoimmune encephalomyelitis (EAE). The neuroactivity of the steroid acts as a therapeutic agent for multiple sclerosis.
Definition
ChEBI: 5alpha-pregnane-3,20-dione is a C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone. It has a role as a human metabolite and a progestogen. It is a 20-oxo steroid, a C21-steroid hormone and a 3-oxo-5alpha-steroid. It is functionally related to a progesterone. It derives from a hydride of a 5alpha-pregnane.
Biochem/physiol Actions
(5α)-Pregnane-3,20-dione is a high-level metabolite of progesterone in breast cancer tissue (but not normal breast tissue); promotes cell proliferation and detachment. Receptors appear only on the cell surface of MCF-7 breast cancer cells, not on nuclei where most other steroid receptors are located.
Biologische Aktivit?t
Digestive gland subcellular fractions readily converted P4 into 5-pregnane-3,20-dione and minor amounts of a second metabolite and then 5-pregnane-3,20-dione was further metabolized to 3-hydroxy-5-pregnane-20-one (3,20-one) by 3β-HSD. This reaction was significantly inhibited by trilostane which is a 3β-HSD inhibitor[1-2].
5-α-Pregnan-3,20-dion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-α-Pregnan-3,20-dion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 167)Lieferanten
566-65-4(5-α-Pregnan-3,20-dion)Verwandte Suche:
(2β,3β,5β,22R)-2,3,14,22,25-Pentahydroxycholest-7-en-6-on
Pregnenolon
Gestrinone
Progesteron
Gestoden
Diethylstilbestrol
Medroxyprogesteronacetat
Pregna-4,16-dien-3,20-dion
Prasteron
17,21-Dihydroxy-5α-pregnan-3,11,20-trion-21-acetat
5-α-Pregnan-3,20-dion
- ALLOPREGNANE-3,20-DIONE
- ALLOPREGNAN-3,20-DIONE
- ALLOPREGNANDIONE
- (5S,8R,9S,10S,13S,14S,17S)-17-ACETYL-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
- 5 A-PREGNANE-3 20-DIONE
- 5A-PREGNAN-3,20-DIONE
- 5ALPHA-PREGNANE-3,20-DIONE (ALLO)
- 5ALPHA-DIHYDROPROGESTERONE
- 5-ALPHA-PREGNAN-3,20-DIONE
- 5A-DIHYDROPROGESTERONE
- (5-alpha)-pregnane-20-dione
- 3,20-Allopregnanedione
- 3,20-Dioxo-5alpha-pregnane
- 5alpha-Pregnane-3,20-dione
- 5-beta-pregnane-3,20-dione
- Pregnane-3,20-dione, (5alpha)-
- 5A-pregnane-3-20-dione-allo
- 5alpha-Pregnan-3,20-dione-1,2,4,5,6,7-D6
- 5α-pregnane-3,20-dione (allo)
- (5S,8R,9S,10S,13R,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
- 4-07-00-02199 (Beilstein Handbook Reference)
- 5 A-PREGNANE-3 20-DIONE 99%
- 5α-Pregnan-3,20-dione-1,2,4,5,6,7-D6
- 5α-Dihydroprogesterone, Allopregnane-3,20-dione
- (5S,8R,9S,10S,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
- Allopregnanedione
- ALLOPREGNENDIONE(RG)(CALL)
- 5α-Pregnane-3,20-dione (allo),5α-Dihydroprogesterone, Allopregnane-3,20-dione
- Hydrogenated progesterone
- 5alpha-Pregnane-3,20-dione (allo) progesterone metabolite
- (8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
- (8R,9S,10S,13S,14S,17S)-17-ethanoyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
- 5-Alpha-Dihydro Progesterone-d8
- Pregnane-3,20-dlone
- Pregnane-3,20-dione, (5α)-
- PREGNANE-3,20-DIONE CAS NO 566-65-4
- 5-alpha-Dihydroprogesterone ISO 9001:2015 REACH
- Estrone Impurity 23
- 566-65-4 5-alpha-Dihydroprogesterone
- Pregnane-3,20-dione
- 5α-dihydroprogesterone
- 5α-pregnane-3,20-dione
- 5α-Dihydroprogesterone
- 5a-Pregnane-3,20-Dione(Dihydroprogesterone)
- (5S,8R,9S,10S,13S,14S,17S)-17-Acetyl-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- Pregnenolone Impurity 13
- 5α-PREGNAN-3, 20-DIONE
- 566-65-4
- Steroids
- 566-65-4