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[R-(R*,R*)]-2-[2-[1-(p-Chlorphenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidiniumhydrogenfumarat

Clemastine fumarate Struktur
14976-57-9
CAS-Nr.
14976-57-9
Bezeichnung:
[R-(R*,R*)]-2-[2-[1-(p-Chlorphenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidiniumhydrogenfumarat
Englisch Name:
Clemastine fumarate
Synonyma:
hs592;tavist;Alagyl;agasten;lecasol;piloral;reconin;tavegil;tavegyl;trabest
CBNumber:
CB0376055
Summenformel:
C25H30ClNO5
Molgewicht:
459.96
MOL-Datei:
14976-57-9.mol

[R-(R*,R*)]-2-[2-[1-(p-Chlorphenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidiniumhydrogenfumarat Eigenschaften

Schmelzpunkt:
158-162°C
alpha 
D21 +16.9° (methanol)
Siedepunkt:
154°C (rough estimate)
Dichte
1.0247 (rough estimate)
Brechungsindex
1.5790 (estimate)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble5mg/mL (clear solution; warmed)
Aggregatzustand
powder
Farbe
white to beige
Optische Aktivit?t
[α]/D +15 to +25°, c = 1 in methanol
InChIKey
PMGQWSIVQFOFOQ-YKVZVUFRSA-N
CAS Datenbank
14976-57-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. UY0704600
HS Code  2933992600
Giftige Stoffe Daten 14976-57-9(Hazardous Substances Data)
Toxizit?t LD50 in mice, rats (mg/kg): 730, 3550 orally; 43, 82 i.v. (Weimann)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

[R-(R*,R*)]-2-[2-[1-(p-Chlorphenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidiniumhydrogenfumarat Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White Solid

Verwenden

Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.

Definition

ChEBI: The fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin condi ions.

Allgemeine Beschreibung

Dextrorotatory clemastine, R,R-2[2[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1- methylpyrrolidine hydrogen furnarate (1:1) (Tavist), has two chiral centers, each of which has the (R) absolute configuration. A comparison of the activities of the enantiomers indicates that the asymmetric center close to the terminal side chain nitrogen is of lesser importance to antihistaminic activity.
? This member of the ethanolamine series is characterized by a long duration of action, with an activity that reaches a maximum in 5 to 7 hours and persists for 10 to 12 hours. It is well absorbed when administered orally, and it is excreted primarily in the urine. The side effects are those usually encountered with this series of antihistamines. Clemastine is closely related to chlorphenoxamine, which is used for its central cholinergic-blocking activity. Therefore, it is not surprising that clemastine has significant antimuscarinic activity.

Biologische Aktivit?t

H 1 -receptor antagonist. Clinically-used antihistamine.

[R-(R*,R*)]-2-[2-[1-(p-Chlorphenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidiniumhydrogenfumarat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


[R-(R*,R*)]-2-[2-[1-(p-Chlorphenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidiniumhydrogenfumarat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 318)Lieferanten
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Hebei Mojin Biotechnology Co., Ltd
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14976-57-9([R-(R*,R*)]-2-[2-[1-(p-Chlorphenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidiniumhydrogenfumarat)Verwandte Suche:


  • CLEMASTINE FUMARATE
  • CLEMASTINE FUMARATE SALT
  • (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrro
  • (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrroli
  • (+)-lfumarate(1:1)
  • 1-methyl-2-(2-(methyl-p-chlorodiphenylmethyloxy)ethyl)pyrrolidine
  • (2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE
  • 2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine
  • agasten
  • aloginan
  • alphamin
  • anhistan
  • clemanil
  • clemastinehydrogenfumarate
  • fuluminol
  • hs592
  • inbestan
  • kinotomin
  • lacretin
  • lecasol
  • lidinefumarate
  • maikohis
  • mallermin-f
  • marsthine
  • masletine
  • meclastine
  • meclastinehydrogenfumarate
  • mecloprodine
  • piloral
  • pyrrolidine,2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methy
  • reconin
  • tavegil
  • tavegyl
  • tavist
  • telgin-g
  • trabest
  • 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt
  • Meclastine fumarate salt
  • Clemastine hydrochloride
  • [R-(R*,R*)]-2-[2-[1-(p-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidinium hydrogen fumarate
  • (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid
  • (+)-2-(2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine
  • Alagyl
  • Tavegul
  • CLEMASTINEFUMARATE,USP
  • (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate
  • Meclastine fumarate
  • Pyrrolidine, 2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, (2R)-, (2E)-2-butenedioate (1:1)
  • Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)-, fumarate (1:1) (8CI)
  • Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-, (E)-2-butenedioate (1:1)
  • Xolamin
  • Clemastine Fgumarate
  • clemastine fumurate
  • Clemastine Fumarate (250 mg)
  • (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-Methylpyrrolidine (2E)-2-Butenedioate
  • Clemastine for system suitability
  • (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt
  • (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt
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