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Huperzine A

Huperzine A Struktur
120786-18-7
CAS-Nr.
120786-18-7
Englisch Name:
Huperzine A
Synonyma:
SELAGINE;HUPERAZINE A;HUPERZINE A;[+/-]-SELAGINE;(+/-)-SELAGINE;(+/-)-HuperzineA;(+/-)-HUPERZINE A;(+/-)-HUPERAZINE A;(±)-Huperzine A, >98%;Huperzine A USP/EP/BP
CBNumber:
CB0308078
Summenformel:
C15H18N2O
Molgewicht:
242.32
MOL-Datei:
120786-18-7.mol

Huperzine A Eigenschaften

Siedepunkt:
505.0±50.0 °C(Predicted)
Dichte
1.20±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO : ≥ 50 mg/mL (206.34 mM)
pka
12.25±0.60(Predicted)
Aggregatzustand
solid
Farbe
White or off-white
InChI
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
InChIKey
ZRJBHWIHUMBLCN-QDEBKDIKSA-N
SMILES
C12CC3/C(=C\C)/C(N)(C=1C=CC(=O)N2)CC(C)=C3
CAS Datenbank
120786-18-7
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 23/24/25-36/37/38
S-S?tze: 26-36/37/39-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS-Nr. PB9185700
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Huperzine A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Huperzine A is an alkaloid extract derived from the Chinese club moss Huperzia serrata. It is an acetylcholinesterase inhibitor. This means it helps promote higher levels of acetylcholine in the brain. Higher levels of acetylcholine support ones ability to perform cognitive tasks such as learning new things, memorizing information, and focusing at the task at hand. Huperzine A is considered to be a nootropic supplement because it supports cognitive function. It is considered a focus and memory nootropic similar to alpha gpc, bacopa, phosphatidylcholine, cdp choline, sulbutiamine, and uridine. It is also considered a brain booster as it is used for brain health and support.
Huperzine A for many years has been widely used in traditional Chinese medicine to enhance memory and to treat fever and inflammation. In the United States it is commercially available as a food supplement, but has not been approved by the FDA as a treatment for AD or other cognition disorders.

Occurrence

The herbs of Lycopodium serratum.

Verwenden

Huperzine A is used for dementia in Alzheimer's disease and for muscle weakness in myasthenia gravis. In Alzheimer's disease, Huperzine A leads to significant improvements in memory and cognitive and behavioral function.

Application

(+/-)-Huperzine A is an NMDA antagonist. It has been used in anti-acetylcholinesterase bioautographic assay.

benefits

Huperzine A can help support learning and memory by protecting acetylcholine, a neurotransmitter that acts as a messenger molecule in the brain. Huperzine A may be used for both short-term "brain boost" needs, such as preparing for a test, as well as more long-term needs, such as reducing the mild memory loss associated with normal aging.
ACETYLCHOLINESTERASE INHIBITOR - Huperzine A acts as a reversible Acetylcholinesterase inhibitor meaning it supports levels of the neurotransmitter acetylcholine which plays a key role in cognitive function.
SUPPORTS COGNITIVE FUNCTION - Supports working memory, motivation, and problem solving ability.
SUPPORTS ENERGY AND STAMINA - Huperzine A supports mental energy, stamina, and sustained focus.

Biologische Aktivit?t

Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.

Nebenwirkungen

When taken at recommended doses Huperzine A is well tolerated and presents few side effects. Rarely, side effects including nausea, diarrhea, and loss of appetite may occur. Adverse side effects are more likely when exceeding the recommended dosage.
Huperzine A is not recommended for people suffering from heart conditions, consult your physician before taking this product.

Mode of action

Huperzine A is a reversible acetycholinesterase inhibitor that can cross the blood-brain barrier. This constituent can inhibit the activity of acetycholinesterase in the brain for several hours, which allows for increased levels of acetylcholine in different areas of the brain. Because of its effects on acetylcholine, Huperzine A is considered a beneficial therapuetic agent in the treatment of memory impairment, myasthenia gravis, and dementia.
Herbs and Nutrients for the Mind A Guide to Natural Brain Enhancers By Chris D. Meletis, Jason E. Barker · 2004

Huperzine A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Huperzine A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 198)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Nutra Biotechnology Co.,Ltd
+8617786394783
nutrabiotech@outlook.com China 300 58
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213302 +86-18374838656
info@staherb.cn China 1025 58
Suzhou Laing Biotechnology Co.,Ltd
+86-13004516015 +86-18149392822
christina@laingbiotec.com China 777 58
Shaanxi LonierHerb Bio Technology Co Ltd
+86-86-+86-86-029-87551862 +8617702909819
sales006@ingredients-lonier.com China 2608 58
Chengdu ChenLv Herb Co.,Ltd
+86-13608205856; +undefined13608205856
maryextract@126.com China 127 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hong Kong Excellence Biotechnology Co., Ltd.

ada@sh-teruiop.com China 875 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55

120786-18-7()Verwandte Suche:


  • (+/-)-SELAGINE
  • [+/-]-SELAGINE
  • 1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
  • (+/-)-HUPERAZINE A
  • (+/-)-HUPERZINE A
  • HUPERZINE A
  • ((plusmn))-Huperzine A
  • (11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
  • (±)-Huperzine A, >98%
  • Huperzia Serrata Extract (Standard)
  • 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (11E)-
  • (+/-)-HuperzineA
  • Huperzine A USP/EP/BP
  • (±)-Huperzine A solution
  • HUPERAZINE A
  • SELAGINE
  • (E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
  • Cholinesterase (ChE),inhibit,Inhibitor,(±)-Huperzine A,(±) Huperzine A,(±)Huperzine A
  • 120786-18-7
  • Cholinesterase, acetyl
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • A to C
  • Biochemicals and Reagents
  • BioChemical
  • Herb extract
  • Natural Plant Extract
  • Acetylcholine receptor
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