Prinomastat
|
|
|
- CAS-Nr.
- 192329-42-3
- Englisch Name:
- Prinomastat
- Synonyma:
- Ag3340;Ag 3340;Ag-3340;KB-R 9896;Prinomastat;AG3340 hydrochloride;AG 3340 hydrochloride;AG-3340 hydrochloride;Phenprobamate Impurity 2;Prinomastat hydrochloride
- CBNumber:
- CB01475597
- Summenformel:
- C18H21N3O5S2
- Molgewicht:
- 423.51
- MOL-Datei:
- 192329-42-3.mol
|
Prinomastat Eigenschaften
- Schmelzpunkt:
- 149.8°
- Dichte
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- H2O: soluble15mg/mL (clear solution)
- Aggregatzustand
- powder
- pka
- 9.25±0.23(Predicted)
- Farbe
- white to beige
- Wasserl?slichkeit
- H2O: 15mg/mL (clear solution)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
|
|
| R-S?tze: |
60-61 |
|
|
| S-S?tze: |
53-45 |
|
|
| WGK Germany |
3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
|
Prinomastat Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Treatment of HaCaT-ras A-5RT3 tumor xenografts with Prinomastat (Ag3340) for 6 days strongly reduces tumor invasion and vascularization. Prinomastat is also a broad spectrum MMP inhibitor
Allgemeine Beschreibung
Prinomastat comprises hydroxamic acid group and chelates with zinc ion.
Enzyminhibitor
C113282), also known as AG3340, inhibits a number of matrix metalloproteinases, including collagenase-3 (Ki = 38 pM), gelatinase A (Ki = 83 pM), stromelysin 1 (Ki = 0.27 nM), and interstitial collagenase (Ki = 8.2 nM). Note that both the 3- and 4-pyridyl structures have been reported for prinomastat; however, the 4-analogue is the original structure reported for this inhibitor. Target(s): ADAM 17 endopeptidase, or tumor necrosis factor-a converting enzyme, or TACE; ADAMTS-4 endopeptidase, or aggrecanase; collagenase-3; gelatinase A; gelatinase B; interstitial collagenase; matrilysin; membrane-type matrix metalloproteinase-1, or matrix metalloproteinase 14; and stromelysin 1.
Prinomastat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Prinomastat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 32)Lieferanten
192329-42-3()Verwandte Suche:
- (S)-2,2-DIMETHYL-N-HYDROXY-4-[4-(4-PYRIDYLOXY)PHENYLSULFONYL]-1,4-THIAZINANE-3-CARBOXAMIDE
- 3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-((4-(4-pyridinyloxy)phenyl)sulfonyl)-, (S)-
- Ag 3340
- Ag3340
- Ag-3340
- KB-R 9896
- (S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride
- AG 3340 hydrochloride
- AG3340 hydrochloride
- 2-[(hydroxyamino)methyl]-5,6-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonyl-morpholine-3-thione
- (S)-2-[(Hydroxyamino)methyl]-5,6-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylmorpholine-3-thione
- Prinomastat
- AG-3340 hydrochloride
- Prinomastat hydrochloride
- (3S)-N-hydroxy-2,2-dimethyl-4-[4-(pyridin-4-yloxy) benzenesulfonyl]thiomorpholine-3-carboxamide
- 3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-, (3S)-
- (S)-N-Hydroxy-2,2-dimethyl-4-((4-(pyridin-4-yloxy)phenyl)sulfonyl)thiomorpholine-3-carboxamide
- Phenprobamate Impurity 2
- 192329-42-3
