成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Betahistin

Betahistine Struktur
5638-76-6
CAS-Nr.
5638-76-6
Bezeichnung:
Betahistin
Englisch Name:
Betahistine
Synonyma:
Y-G 14-d3;PT 9 base;Serc base;Vasomotal;β-Histine;BETAHISTINE;NSC 42617-d3;AKOS BBS-00002883;Sinmenier (free base);Betahistine Impurity 23
CBNumber:
CB4489793
Summenformel:
C8H12N2
Molgewicht:
136.19
MOL-Datei:
5638-76-6.mol

Betahistin Eigenschaften

Siedepunkt:
113-114 °C30 mm Hg(lit.)
Dichte
0.984 g/mL at 25 °C(lit.)
Dampfdruck
17.7Pa at 25℃
Brechungsindex
n20/D 1.518(lit.)
Flammpunkt:
206 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
pKa 3.46 (Uncertain)
Aggregatzustand
Oil
Farbe
Light Yellow to Yellow
Wasserl?slichkeit
1000g/L at 25℃
Merck 
13,1181
LogP
0.68
CAS Datenbank
5638-76-6(CAS DataBase Reference)
EPA chemische Informationen
2-Pyridineethanamine, N-methyl- (5638-76-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,C
R-S?tze: 36/37/38
S-S?tze: 26-37/39
WGK Germany  2
RTECS-Nr. UT5552000
Hazard Note  Corrosive
HS Code  2933399990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Betahistin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Betahistine is an analogue of histamine with weak agonist properties at histamine H1 receptors and more potent antagonistic effects at histamine H3 receptors.
This drug is broadly used worldwide, except for the USA, since it has not been approved by the US Food and Drug Administration. Betahistine is a structural analog of histamine that acts as a weak partial postsynaptic histamine H1 receptor agonist and presynaptic H3 receptor antagonist, with no effect on postsynaptic H2 receptors (Gbahou et al, 2010). The mechanism of action of the drug appears to depend mainly on its action on H3 receptors mediated by two metabolites, aminoethylpyridine and hydroxyethylpyridine (Bertich et al, 2014).

Verwenden

Betahistine is a vasodilator, a mild H1 histamine agonist, and a potent H3 histamine antagonist. The mechanism of action in Meniere's disease is unknown, but theories include reducing the endolymphatic pressure through improved circulation in the stria vascularis or inhibiting activity in the vestibular nuclei. It has been found to be a safe drug with a very low side effect profile. Betahistine was FDA approved for Meniere's disease in the US market for a short period of time in the 1970s, but approval was then rescinded due to lack of evidence supporting its efficacy. However, based on clinical experience and several observational studies, it is still widely used elsewhere in the world.

Indications

Betahistine is indicated in treatment of Meniere's disease (vertigo, hearing loss and tinnitus); it is not effective in preventing vertigo attacks.

Mechanism of action

The precise mechanism of betahistine's actions is unclear; it has antagonistic actions on histamine H3 receptors, and is a weak agonist at H receptors. In animal studies, it inhibits generation of spikes in vestibular nuclei. Its vasodilator activity (similar to histamine's) presumably improves blood flow in the inner ear and brainstem.

Pharmakokinetik

After oral administration, betahistine is rapidly and completely absorbed, rapidly metabolised (to one major metabolite, 2-pyridylacetic acid) and 90% excreted within 24 hours. Plasma and urinary half-lives are about 3.5 hours.

Nebenwirkungen

Common adverse reactions include headache, nausea and dyspepsia. More rarely, hypersensitivity reactions (rash, pruritis, bronchospasm) and hypotension may occur.

Arzneimittelwechselwirkung

Co-administration of betahistine and monoamine oxidase inhibitors type B reduces metabolism of betahistine. Theoretically, interactions might occur with concurrent antihistamines; however, no significant problems have been reported.

Vorsichtsma?nahmen

Betahistine should be used with caution in individuals with asthma, urticaria, phaeochromocytoma or hypersensitivity to any components of tablets. Betahistine is contraindicated in people with active or history of peptic ulcer. Betahistine is classified in Pregnancy Safety Category B2: insufficient data available; it is contraindicated in pregnancy and lactation, and in children under 18.

Betahistin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Betahistin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 145)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou Benoy Chemical Co., Ltd
+8617342059697
sales@benoychem.com China 315 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
JIAXING REGEN CHEMICAL CO.,LTD
+8613385739570
regen_chemical1@163.com China 226 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 11817 58

5638-76-6(Betahistin)Verwandte Suche:


  • N-Methyl-N-(2-pyridin-2-ylethyl)amine
  • METHYL-(2-PYRIDIN-2-YL-ETHYL)-AMINE
  • BETAHISTINE
  • AKOS BBS-00002883
  • 2'-(2-N-METHYLAMINO ETHYL)PYRIDINE
  • 2-(2-METHYLAMINOETHYL)PYRIDINE
  • 2-[B-(METHYLAMINO)ETHYL]PYRIDINE
  • 2-(METHYLAMINOETHYL)PYRIDINE
  • N-METHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE
  • (2-(2-pyridyl)ethyl)methylamine
  • [2-(2-Pyridyl)ethyl]methylamine
  • 2-(2-(methylamino)ethyl)-pyridin
  • 2-(beta-Methylaminoethyl)pyridine
  • 2-Pyridineethanamine, N-methyl-
  • N-Methyl-2-(2-pyridinyl)ethanamine
  • 2-[-(Methyl-d3)aminoethyl]pyridine
  • 2-[2-(Methyl-d3)aminoethyl]pyridine
  • N-(Methyl-d3)-2-pyridineethanamine
  • N-(Methyl-d3)-N-[2-(pyridin-2-yl)ethyl]amine
  • NSC 42617-d3
  • Y-G 14-d3
  • n-methyl-2-pyridineethanamin
  • n-methyl-2-pyridineethanamine
  • N-Methyl-2-pyridineethylamine
  • N-Methyl-N-beta-(2-pyridyl)ethylamine
  • PT 9 base
  • Pyridine, 2-[2-(methylamino)ethyl]-
  • Serc base
  • Sinmenier (free base)
  • Vasomotal
  • N-Methyl-2-(2-pyridyl)ethylamine
  • β-Histine
  • 2-(2-Methylaminoethyl)pyridine ,97%
  • n-Methyl-n-[2-(2-pyridyl)amine, 97+%
  • 2-(2-Methylaminoethyl)pyridine ,95%
  • 2-(2-METHYLAMINOETHYL)PYRIDINE USP/EP/BP
  • PT 9 base|||Vasomotal|||Serc base
  • Betahistine Impurity 23
  • 5638-76-6
  • C8H9D3N2
  • AMINE
  • C7 and C8
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyridines
  • C7 and C8
  • Heterocyclic Building Blocks
  • Pyridines
  • Aromatics
  • Heterocycles
  • Isotope Labeled Compounds
Copyright 2019 ? ChemicalBook. All rights reserved