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Nelarabine

Nelarabine Struktur
121032-29-9
CAS-Nr.
121032-29-9
Englisch Name:
Nelarabine
Synonyma:
MAY;Arranon;Nelzarabine;506u;506U78;CS-1953;GW 506U78;NELARABIN;NELARABINE;Nelarabine D4
CBNumber:
CB01011878
Summenformel:
C11H15N5O5
Molgewicht:
297.27
MOL-Datei:
121032-29-9.mol

Nelarabine Eigenschaften

Schmelzpunkt:
209-217°
alpha 
D20 +55.9° (c = 0.27 in DMF)
Siedepunkt:
721.0±70.0 °C(Predicted)
Dichte
1.98±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)
Aggregatzustand
Solid
pka
13.07±0.70(Predicted)
Farbe
White
InChI
InChI=1/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/s3
InChIKey
IXOXBSCIXZEQEQ-GCTRTDOSNA-N
SMILES
N1(C=NC2C(OC)=NC(N)=NC1=2)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:12,13,15,17,r|
CAS Datenbank
121032-29-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Nelarabine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nelarabine is a new member of the purine nucleoside antimetabolite class of drugs. It was launched as an intravenous infusion for treating relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) after at least two prior chemotherapy regimens. Nelarabine is a pro-drug of 9-b-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative with a high level of T-cell selective cytotoxicity. Although Ara-G has been known since the 1960s, it has not been used in clinical studies due to its poor solubility. Nelarabine is the O-methyl derivative of ara-G with approximately 10 times greater aqueous solubility. It is demethylated in vivo by adenosine deaminase to produce ara-G, which is subsequently converted to the active 5’-triphosphate, ara-GTP. Accumulation of ara-GTP in leukemic blasts allows for incorporation into DNA, leading to inhibition of DNA synthesis and cell death.

Verwenden

A chemotherapy drug used in the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).

Definition

ChEBI: Nelarabine is a purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G). It has a role as an antineoplastic agent, a DNA synthesis inhibitor and a prodrug. It is a purine nucleoside, a beta-D-arabinoside and a monosaccharide derivative. It is functionally related to a guanine and a 9-beta-D-arabinofuranosylguanine.

Nelarabine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Nelarabine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 250)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Nanjing Baifuli Technology Co., Ltd.
+86-15335185688
sales@unisyn.cn CHINA 332 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58

121032-29-9()Verwandte Suche:


  • (2R,3S,4S,5R)-2-(2-AMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
  • 506U78
  • (2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine
  • NELARABINE
  • Nelzarabine [USAN]
  • 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
  • Nelarabine (Arranon)
  • 506u
  • 9-β-D-Arabinofuranosyl-6-Methoxy-9H-purin-2-aMine
  • GW 506U78
  • (2R,3R,4S,5R)-2-(2-aMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)-tetrahydrofuran-3,4-diol
  • NELARABIN
  • 9H-Purin-2-aMine, 9-b-D-arabinofuranosyl-6-Methoxy-
  • Nelarabine (506U78)
  • Nelarabine USP/EP/BP
  • Nelarabine D4
  • CS-1953
  • Nelzarabine
  • Arranon
  • MAY
  • Nelarabine/Arranon/506U78
  • 9H-Purin-2-amine, 9-β-D-arabinofuranosyl-6-methoxy-
  • 121032-29-9
  • 121032-29-2
  • 1201032-29-9
  • API
  • Inhibitors
  • 5g,10g,25g,100g
  • ARRANON
  • Anti-cancer&immunity
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Bases & Related Reagents
  • 121032-29-9
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