PJ-34
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- CAS號(hào):
- 344458-19-1
- 英文名:
- PJ-34
- 英文別名:
- PJ-34;CS-856;PJ34(free base);PJ34;PJ-34;PJ 34;PJ34 PJ-34 A3729 A-3729;2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;PJ34,Inhibitor,PJ-34,PJ 34,PARP,inhibit,poly ADP ribose polymerase
- 中文名:
- PJ-34
- 中文別名:
- 化合物PJ34;PJ34(游離);PJ34,PARPL/2 抑制劑;2-(二甲氨基)-N-(6-氧代-5,6-二氫菲-2-基)乙酰胺;2-(二甲基氨基)-N-(6-氧代-5,6-二氫菲啶-2-基)乙酰胺;N-(6-氧代-5,6-二氫菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺
- CBNumber:
- CB3434387
- 分子式:
- C17H17N3O2
- 分子量:
- 295.34
- MOL File:
- Mol file
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PJ-34化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Solid
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顏色:
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Light yellow to khaki
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PJ-34性質(zhì)、用途與生產(chǎn)工藝
PJ34 是一種有效的特異性 PARPl/2 抑制劑，IC50 分別為 110 nM 和 86 nM。
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PARP
110 nM (IC
50
)
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PARP-2
86 nM (IC
50
)
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PARP-1
110 nM (IC
50
)
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PJ34 inhibits the PARP enzyme activity with an IC
50
of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10
-7
to 10
-5
M.
To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
PJ-34
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-13688A | PJ34 | | 5 mg | 356元 |
| 2024/11/08 | HY-13688A | PJ-34
PJ34 | 344458-19-1 | 10mg | 570元 |
344458-19-1, PJ-34 相關(guān)搜索:
- Inhibitors
- 抑制劑
- 合成有機(jī)化合物配體
- DNA損傷
- 小分子抑制劑，天然產(chǎn)物
- PJ34,PARPL/2 抑制劑
- 2-(二甲氨基)-N-(6-氧代-5,6-二氫菲-2-基)乙酰胺
- 化合物PJ34
- 2-(二甲基氨基)-N-(6-氧代-5,6-二氫菲啶-2-基)乙酰胺
- PJ34(游離)
- N-(6-氧代-5,6-二氫菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺
- 344458-19-1
- PJ34,Inhibitor,PJ-34,PJ 34,PARP,inhibit,poly ADP ribose polymerase
- PJ34 PJ-34 A3729 A-3729
- 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
- 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
- CS-856
- PJ34;PJ-34;PJ 34
- N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide
- N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide
PJ 34
- Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-
- PJ34(free base)
- PJ-34
- N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE
- N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL
- N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide