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959-23-9

中文名稱 4'-甲氧基查耳酮
英文名稱 4'-METHOXYCHALCONE
CAS 959-23-9
EINECS 編號 213-495-5
分子式 C16H14O2
MDL 編號 MFCD00008407
分子量 238.28
MOL 文件 959-23-9.mol
更新日期 2023/03/20 19:41:21
959-23-9 結構式 959-23-9 結構式

基本信息

中文別名
4'-甲氧基查耳酮,97%
1-(4-甲氧基苯基)-3-苯基丙-2-烯-1-酮
英文別名
1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE
2-BENZYLIDENE-4'-METHOXYACETOPHENONE
4'-METHOXYCHALCONE
(E)-1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE
METHOXYCHALCONE, 4'-
RARECHEM AM UC 0609
alpha-styryl p-anisyl ketone
4'-METHOXYCHALCONE 97%
Benzylidene(4-methoxyacetophenone)
4'-Methoxychalcone,97%
1-(4-Methoxyphenyl)-3-phenyl-2-propen-1-one
4-Methoxyphenylstyryl ketone
Styryl(4-methoxyphenyl) ketone
β-Phenyl-4'-methoxyacrylophenone
所屬類別
生物化工:提取物

物理化學性質

熔點101-103 °C(lit.)
沸點397.5±42.0 °C(Predicted)
密度1.114±0.06 g/cm3(Predicted)
形態(tài)Solid
顏色White to light yellow
水溶解性Soluble in dichloromethane and methanol. Insoluble in water.
BRN644640
LogP4.180 (est)

安全數據

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
危險品標志Xi
危險類別碼R36/37/38
安全說明S26-S36
WGK Germany3

知名試劑公司產品信息

Alfa Aesar
4'-甲氧基查耳酮價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/11/08B221584’-甲氧基查耳酮, 97%
4'-Methoxychalcone, 97%
959-23-95g298元
2024/11/08B221584’-甲氧基查耳酮, 97%
4'-Methoxychalcone, 97%
959-23-925g736元
2024/11/08B221584’-甲氧基查耳酮, 97%
4'-Methoxychalcone, 97%
959-23-9100g1496元

常見問題列表

生物活性
4'-Methoxychalcone存在于柑橘屬植物中,是一種查耳酮衍生物,具有多種藥理活性,如抗腫瘤和消炎活性。
靶點

PPARγ

體外研究

4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4. 4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells. 4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected.

RT-PCR

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days
Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte.

Western Blot Analysis

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 8 days
Result: Increased PPARγ expression in adipocyte.
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