935693-62-2
中文名稱
BIX 01294
英文名稱
BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
CAS
935693-62-2
分子式
C28H38N6O2
分子量
490.64
MOL 文件
935693-62-2.mol
更新日期
2024/10/28 14:46:37
935693-62-2 結(jié)構(gòu)式
基本信息
中文別名
BIX01294游離BIX 01294 三鹽酸鹽 水合物
N-(1-芐基哌啶-4-基)-6,7-二甲氧基-2-(4-甲基-1,4-二氮雜環(huán)庚-1-基)喹唑啉-4-胺
2-(六氫-4-甲基-1H-1,4-二氮雜卓-1-基)-6,7-二甲氧基-N-[1-(苯基甲基)-4-哌啶基]-4-喹唑啉胺
BIX 01294,2-(六氫-4-甲基-1H-1,4-二氮雜-1-基)-6,7-二甲氧基-N-[1-(苯基甲基)-4-哌啶基]-4-喹唑啉胺水合三鹽酸鹽
2-(HEXAHYDRO-4-METHYL-1H-1,4-DIAZEPIN-1-YL)-6,7-DIMETHOXY-N-[1-(PHENYLMETHYL)-4-PIPERIDINYL]-4-QUINAZOLINAMINE 三鹽酸鹽 水合物
英文別名
CS-207BIX 01294
BIX01294,BIX-01294
BIX 01294 (free base)
BIX-01294
BIX 01294
BIX01294
BIX 01294 hydrate trihydrochloride
Histone Lysine methyltransferase Inhibitor
Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem
N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trih
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)654.6±65.0 °C(Predicted)
密度1.195±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度可溶于 DMSO（高達(dá) 50 mg/ml）或水（高達(dá) 50 mg/ml）。
酸度系數(shù)(pKa)9.34±0.70(Predicted)
形態(tài)類白色固體
顏色米白色
穩(wěn)定性DMSO或蒸餾水中的溶液可在-20°下穩(wěn)定儲(chǔ)存3個(gè)月。
InChIKeyBZOWJAYUMMHCDW-UHFFFAOYSA-N
常見問題列表
生物活性
BIX-01294 是一種 G9a 組蛋白甲基轉(zhuǎn)移酶 (G9a Histone Methyltransferase) 抑制劑，IC50 值為 1.9 μM。靶點(diǎn)
IC50: 1.9 μM (G9a Histone Methyltransferase)
體外研究
BIX-01294 (4.1 μM) treatment of?G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes.
BIX-01294 (5 μM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy.
BIX-01294 (1 μg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.