821768-06-3
中文名稱
4-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺
英文名稱
4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
CAS
821768-06-3
分子式
C17H15F6N5O
分子量
419.32
MOL 文件
821768-06-3.mol
821768-06-3 結(jié)構(gòu)式
基本信息
中文別名
化合物JNJ-172032124-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺
英文別名
JNJ 17203212JNJ-17203212 (JNJ17203212
N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine
4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-
management,inhibit,pain,migrainem,Transient receptor potential channels,TRP Channel,JNJ-17203212,JNJ17203212,Inhibitor,JNJ 17203212
4-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-100129 | 4-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺 JNJ-17203212 | 821768-06-3 | 5mg | 800元 |
| 2024/08/19 | HY-100129 | 4-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺 JNJ-17203212 | 821768-06-3 | 10mM * 1mLin DMSO | 880元 |
| 2024/08/19 | HY-100129 | 4-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺 JNJ-17203212 | 821768-06-3 | 10mg | 1400元 |
常見問題列表
生物活性
JNJ-17203212 是一種選擇性、高效的，競爭性的 TRPV1 拮抗劑。JNJ-17203212 被開發(fā)用于疼痛處理的研究，如偏頭痛。靶點
|
TRPV1
|
體外研究
JNJ-17203212 (0.5 μM) potently inhibits imperatorin-induced TRPV1 activation (Ca
2+
increases) in TRPV1-expressing HEK cells.
體內(nèi)研究
JNJ-17203212 (0.3 mg/kg ; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression.
JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner.
| Animal Model: | Male Sprague-Dawley rats (260-300 g) |
| Dosage: | 0.3 mg/kg |
| Administration: | Intravenous injection |
| Result: | Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS. |