79644-90-9
79644-90-9 結(jié)構(gòu)式
基本信息
中文別名
維布沙星 英文別名
DM8966OPC-19A
OPC 7241
Flumenique
Benofloxacin
Vebufloxacin
Vebufloxacin USP/EP/BP
8-Fluoro-5,6-dihydro-4-methyl-7-(4-methyl-1-piperazinyl)-1-oxo-4H-3a-aza-1H-phenalene-2-carboxylic acid
9-Fluoro-6,7-dihydro-5-methyl-8-(4-methyl-1-piperazinyl)-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-5-methyl-8-(4-methyl-1-piperazinyl)-1-oxo-
所屬類別
原料藥：喹諾酮類藥物理化學(xué)性質(zhì)
沸點(diǎn)579.1±50.0 °C(Predicted)
密度1.41±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)5.55±0.40(Predicted)
常見問題列表
生物活性
Vebufloxacin (Flumenique; OPC7241; DM8966) 對革蘭氏陽性和陰性菌都具有強(qiáng)的抗菌活性。靶點(diǎn)
Bacteria
體外研究
A series of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids is synthesized and tested for antibacterial activities. Among them, Vebufloxacin (OPC-7241) exhibits potent antibacterial activity against gram-positive and -negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa , and OPC-7251 shows potent activity characteristically against Propionibacterium acnes .