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74103-07-4

中文名稱 酮咯酸氨丁三醇
英文名稱 Ketorolac tromethamine
CAS 74103-07-4
分子式 C19H24N2O6
MDL 編號 MFCD00887595
分子量 376.4
MOL 文件 74103-07-4.mol
更新日期 2025/01/21 20:57:06
74103-07-4 結(jié)構(gòu)式 74103-07-4 結(jié)構(gòu)式

基本信息

中文別名
(+/-)-5-苯甲?;?2,3-二氫-1H-吡咯里嗪-1-甲酸氨丁三醇鹽
酮咯酸氨丁三醇
辛太克斯(浮選劑)
(+/-)-5-苯甲酰基-2,3-二氫-1H-吡咯里嗪-1-甲酸氨丁三醇鹽
英文別名
(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID, TRIS (HYDROXYMETHYL) AMINOMETHANE SALT
(+/-)-5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid tris(hydroxymethyl)methylamine salt
(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID TRIS SALT
KETOROLAC TRIS SALT
KETOROLAC TROMETHAMINE
KETOROLAC TROMETHAMINE SALT
KETROLAC TROMETHAMINE SALT
TORADOL
TORADOL TRIS SALT
3-dihydro-5-benzoyl-(+-)-compd.with2-1h-pyrrolizine-1-carboxylicaci
amino-2-(hydroxymethyl)-1,3-propanediol(1:1)
syntex
KEROROLACTROMETHAMINE
KETOROLACTROMETHAMINE,USP
(+/-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris(hydroxymethyl)methylamine salt
Toradol, (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt
所屬類別
生物化工:COX 抑制劑

物理化學性質(zhì)

熔點160-161 C
儲存條件2-8°C
溶解度H2O: 15 mg/mL stable at least one month at −20 °C., soluble
形態(tài)crystalline
顏色白色至淺黃色
最大波長(λmax)322nm(MeOH)(lit.)
Merck14,5306
穩(wěn)定性吸濕性
InChIInChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChIKeyBWHLPLXXIDYSNW-UHFFFAOYSA-N
SMILESC(N)(CO)(CO)CO.C(C1C=CC=CC=1)(C1=CC=C2C(C(=O)O)CCN12)=O
CAS 數(shù)據(jù)庫74103-07-4(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS06
警示詞危險
危險性描述H301-H315-H319-H335
危險品標志T
危險類別碼R25-R36/37/38
安全說明S26-S45
危險品運輸編號UN 2811 6.1/PG 3
WGK Germany3
RTECS號UY7759900
危險等級6.1(a)
包裝類別II
海關編碼2933995500

常見問題列表

概述
酮咯酸氨丁三醇是醇類有機物,其生物活性與左旋S(-)有關,可抑制前列腺素生物合成。
用途
咯酸氨丁三醇為吡咯烷羧酸衍生物,是由左旋(-)和右旋(+)異構(gòu)體組成的消旋體,其右旋S(+)異構(gòu)體具有止痛作用。
生物活性
Ketorolac tromethamine是一種合成的吡呤環(huán)羧酸衍生物,具有消炎、止痛和退熱活性。它是非選擇性的COX抑制劑,對COX-1和COX-2的IC50值都是20 nM。
靶點
TargetValue
COX1
()
20 nM
COX2
()
20 nM
體外研究

Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC 50 s of 20 nM for COX-1 and 120 nM for COX-2.

體內(nèi)研究

Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits. Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group.

知名試劑公司產(chǎn)品信息

酮咯酸氨丁三醇價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-B0138酮咯酸氨丁三醇
Ketorolac tromethamine salt
74103-07-4500mg600元
2024/11/08HY-B0138酮咯酸氨丁三醇
Ketorolac tromethamine salt
74103-07-410mM * 1mLin DMSO660元
2024/11/08S5698酮咯酸氨丁三醇
Ketorolac tromethamine salt
74103-07-425mg794.85元
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