6698-26-6
6698-26-6 結(jié)構(gòu)式
基本信息
2',5'-雙脫氧腺苷
化合物2',5'-DIDEOXYADENOSINE
2',5'-DD-ADO
2',5'-DIDEOXYADENOSINE
Adenosine, 2',5'-dideoxy-
2',5'-Dideoxyadenosine >=95% (HPLC), solid
2,5-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem
5-(6-AMINOPURIN-9-YL)-2-METHYLTETRAHYDROFURAN-3-OL
(2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-Methyltetrahydrofuran-3-ol
NSC 95943 2',5'-DIDEOXYADENOSINE
phosphoric acid [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl [hydroxy(phosphonooxy)phosphoryl] [(2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] ester
物理化學(xué)性質(zhì)
常見問題列表
IC50: 3 μM (adenylyl cyclase)
2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448.
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
Western Blot Analysis
| Cell Line: | Primary hippocampal neurons |
| Concentration: | 10 μM |
| Incubation Time: | 30 min |
| Result: | Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). |
2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K
+
and Cl
-
sparing effect of Fr?EtOAc in rats.
| Animal Model: | Male Wistar rats (3-4 months old) |
| Dosage: | 0.1 mg/kg |
| Administration: | IP; 15 min pre-treated |
| Result: | Fully inhibited the diuretic, natriuretic and K + and Cl - sparing effect of Fr?EtOAc in rats. |