5957-80-2
5957-80-2 結(jié)構(gòu)式
基本信息
鼠尾草苦內(nèi)脂
鼠尾草酚(標(biāo)準(zhǔn)品)
鼠尾草酚(鼠尾草苦內(nèi)脂)
鼠尾草酚 CARNOSOL
CARNOSOL 鼠尾草酚
鼠尾草苦內(nèi)脂, 迷迭香中提取
鼠尾草苦內(nèi)脂, 來源于迷迭香
鼠尾草酚:鼠尾草苦內(nèi)脂對(duì)照品,
CARNOSOL(RG)
CARNOSOL USP/EP/BP
Carnosol, froM RoseMarinus officinalis
Carnosol, 98%, from Rosemarinus officinalis
1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE
2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
鼠尾草苦內(nèi)脂又叫鼠尾草酚，是一種存在于迷迭香和丹參等植物中的天然二萜化合物，具有很強(qiáng)的降血脂、抗氧化、抗腫瘤、抗病毒和抗炎特性，已廣泛用于保健、食品、天然色素、化妝品等領(lǐng)域，據(jù)報(bào)道，鼠尾草苦內(nèi)脂可以通過抑制NF-κB通路而具有抗腫瘤的作用，也可以誘導(dǎo)T細(xì)胞白血病、淋巴瘤細(xì)胞凋亡并降低血清中的IL-6和TNF-α水平。
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RSK2 ~5.5 μM (IC 50 ) |
Nrf2
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It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1.
Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged.