579-56-6
中文名稱(chēng)
鹽酸苯氧丙酚胺
英文名稱(chēng)
ISOXSUPRINE HYDROCHLORIDE
CAS
579-56-6
EINECS 編號(hào)
209-443-6
分子式
C18H24ClNO3
MDL 編號(hào)
MFCD00058069
分子量
337.84
MOL 文件
579-56-6.mol
更新日期
2023/03/20 15:41:19
579-56-6 結(jié)構(gòu)式
基本信息
中文別名
鹽酸苯氧丙酚胺異舒普林鹽酸鹽
異克舒令
英文別名
ISOXSUPRINE HCLISOXSUPRINE HYDROCHLORIDE
1-(p-hydroxyphenyl)-2-(1’-methyl-2’-phenoxy)ethylaminopropanol-1hydrochlorid
2-(3-phenoxy-2-propylamino)-1-(p-hydroxyphenyl)-1-propanolhydrochloride
isolait
isoxsuprinhydrochloride
p-hydroxy-alpha-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)-benzylalcohohyd
suprilent
vasodilan
vasoplex
Isoxsuprine
Benzenemethanol, 4-hydroxy-.alpha.-1-(1-methyl-2-phenoxyethyl)aminoethyl-, hydrochloride
1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1 hydrochloride
Benzenemethanol, 4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, hydrochloride (9CI)
Benzyl alcohol, p-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, hydrochloride (8CI)
Dilavase
Divadilan
Duvadilan
Duviculine
Navilox
所屬類(lèi)別
分析化學(xué)：法醫(yī)和獸醫(yī)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)203-204°
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in methylene chloride.
酸度系數(shù)(pKa)pKa 8.0 (Uncertain);9.8 (Uncertain)
形態(tài)neat
顏色White to off-white
CAS 數(shù)據(jù)庫(kù)579-56-6(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H410
防范說(shuō)明P264-P270-P273-P301+P312-P391-P501
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類(lèi)別碼R22
安全說(shuō)明S36
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3
RTECS號(hào)DO8225000
海關(guān)編碼2922504500
毒害物質(zhì)數(shù)據(jù)579-56-6(Hazardous Substances Data)
毒性LD50 in rats (mg/kg): 1750 orally; 164 i.p. (Goldenthal)
鹽酸苯氧丙酚胺價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-B1270 | 鹽酸苯氧丙酚胺 Isoxsuprine hydrochloride | 579-56-6 | 200mg | 500元 |
| 2025/02/08 | HY-B1270 | 鹽酸苯氧丙酚胺 Isoxsuprine hydrochloride | 579-56-6 | 10mM * 1mLin DMSO | 660元 |
| 2025/02/05 | S5669 | 鹽酸苯氧丙酚胺 Isoxsuprine hydrochloride | 579-56-6 | 25mg | 794.73元 |
常見(jiàn)問(wèn)題列表
生物活性
Isoxsuprine hydrochloride是β-腎上腺素能受體（beta-adrenergic）激動(dòng)劑，具有血管擴(kuò)張活性。靶點(diǎn)
Ki: 13.65 μΜ (myometrial beta-adrenergic receptor), 3.48 μΜ (placcntal beta-adrenergic receptor)
NMDA receptor
體外研究
Results show that Isoxsuprine hydrochloride inhibits circular chemorepellent induced defect (CCID) formation dose dependently (5 to 60?μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine hydrochloride is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin).
體內(nèi)研究
Total infarct volume in vehicle-treated animals is 279±25 mm 3 compare to 137±18 mm 3 in Isoxsuprine hydrochloride-treated animals.