57-41-0
基本信息
苯妥英
5,5-二苯基乙內(nèi)酰脲
5,5-聯(lián)苯基乙內(nèi)酰脲
二苯基乙內(nèi)醯脲
二苯尿囊素
5,5-DIPHENYLHYDANTHOIN
5,5-DIPHENYLHYDANTOIN
DIPHENYLHYDANTOIN
LABOTEST-BB LT00159593
PHENYTION
PHENYTOIN
PHENYTOIN BASE
2,4-Imidazolidinedione, 5,5-diphenyl-
5,5-diphenyl-hydantoi
5,5-Diphenylimidazolidin-2,4-dione
5,5-Dwufenylohydantoina
Aleviatin
Antisacer
Causoin
Citrullamon
Citrulliamon
Comital
Comitoina
component of Mebroin
物理化學性質(zhì)
安全數(shù)據(jù)
常見問題列表
苯妥英是一種抗癲癇藥,用于治療多種癲癇發(fā)作。它也是一種Vaughan-WilliamsⅠB類抗心律失常藥,但目前極少用于治療心律失常。
苯妥英常見副作用包含惡心、胃痛、缺乏食欲、肢體協(xié)調(diào)不良、毛發(fā)增長,以及牙齦增生。其他可能的嚴重副作用則包含嗜睡、自殘、肝臟問題、骨髓抑制、低血壓,以及毒性表皮溶解癥。
Target | Value |
Sodium channel |
Phenytoin is an antiepileptic drug. It is useful to partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels.
Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials.
When neurons are depolarized and the channels transition into the open and inactivated states, greater binding and block occur. The inhibitory potency is strongly use dependent, so that block accumulates with prolonged or repetitive activation, such as occurs during a seizure discharge. The blocking of sodium channels by phenytoin is of slow onset. The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity. Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control. Phenytoin is a class 1b antiarrhythmic.
Phenytoin (5,5-Diphenylhydantoin; 60 mg/kg; daily; 28 days ) reduces tumour growth in six week-old female Rag2 -/- Il2rg -/- mice with MDA-MB-231 cells.
知名試劑公司產(chǎn)品信息
5,5-Diphenylhydantoin, 99+%(57-41-0)