成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>54857-86-2

54857-86-2

中文名稱(chēng) 5-(十四烷基氧)-2-糠酸
英文名稱(chēng) 5-(TETRADECYLOXY)-2-FUROIC ACID
CAS 54857-86-2
分子式 C19H32O4
分子量 324.45
MOL 文件 54857-86-2.mol
更新日期 2025/04/09 10:33:40
54857-86-2 結(jié)構(gòu)式 54857-86-2 結(jié)構(gòu)式

基本信息

中文別名
化合物TOFA
5-(十四烷氧基)-2-糠酸
5-(十四烷基氧)-2-糠酸
乙酰輔酶A羧化酶-Α(ACCA)變構(gòu)抑制劑(TOFA)
英文別名
TOFA
mdl14514
RMI-14514
TOFA (RMI14514
RMI14514
MDL14514
TOFA (RMI14514:MDL14514)
5-tetradecyloxy-2-furonicacid
5-(TETRADECYLOXY)-2-FUROIC ACID
5-(TETRADECYLOXY)-2-FUROIC TOFA
TOFA - CAS 54857-86-2 - Calbiochem
所屬類(lèi)別
生物:小分子化合物

物理化學(xué)性質(zhì)

熔點(diǎn)112-115 °C
沸點(diǎn)441.7±25.0 °C(Predicted)
密度1.003±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度DMSO: 2.5 mg/mL
酸度系數(shù)(pKa)3.55±0.10(Predicted)
形態(tài)solid
顏色白色至米色
穩(wěn)定性可在-20°下的DMSO或乙醇溶液保存長(zhǎng)達(dá)1個(gè)月。

安全數(shù)據(jù)

WGK Germany2
RTECS號(hào)LU0288000
海關(guān)編碼29321900

常見(jiàn)問(wèn)題列表

應(yīng)用
5-(十四烷基氧)-2-糠酸可作為有機(jī)合成中間體和醫(yī)藥中間體,可用于實(shí)驗(yàn)室研發(fā)過(guò)程和化工醫(yī)藥生產(chǎn)過(guò)程中。
生物活性
TOFA (5-(Tetradecyloxy)-2-furoic acid, Tyrphostin 46,Tyrphostin A46,Tyrphostin B40)是acetyl-CoA carboxylase-α (ACCA)的變構(gòu)抑制劑。在細(xì)胞內(nèi)TOFA轉(zhuǎn)化為T(mén)OFyl-CoA (5-tetradecyloxy-2-furoyl-CoA),對(duì)ACCA具有變構(gòu)抑制作用。 TOFA阻止脂肪酸合成,并以劑量依賴(lài)性方式誘導(dǎo)細(xì)胞死亡。
靶點(diǎn)
TargetValue
ACCA
()
體外研究

TOFA (5-tetradecyloxy-2-furoic acid) is cytotoxic to lung cancer cells NCI-H460 and colon carcinoma cells HCT-8 and HCT-15, with an IC 50 at approximately 5.0, 5.0, and 4.5 μg/mL, respectively. TOFA at 1.0–20.0 μg/mL effectively blocks fatty acid synthesis and induces cell death in a dose-dependent manner. TOFA is found to be cytotoxic to COC1 and COC1/DDP cells with IC 50 values of ~26.1 and 11.6 μg/mL, respectively. TOFA inhibits the proliferation of the cancer cells examined in a time and dose dependent manner, arrests the cells in the G0/G1 cell cycle phase and induces apoptosis. Acetyl-CoA-carboxylase-α (ACCA) is a key enzyme in the regulation of fatty acids synthesis. Inhibition of ACCA by TOFA decreases fatty acid synthesis and induces caspase activation and cell death in most PCa cell lines.

體內(nèi)研究

TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. The tumor growth rate is signifi?cantly inhibited by TOFA compared with the DMSO treated control mice (1649±356.3 vs. 5128±390.4 mm 3 . No toxicity is observed in the heart, liver, spleen, lung, kidney and intestinal tissues. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy.

5-(十四烷基氧)-2-糠酸價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/02/08HY-1010685-(十四烷基氧)-2-糠酸
TOFA
54857-86-21 mg250元
2025/02/08HY-1010685-(十四烷基氧)-2-糠酸
TOFA
54857-86-25mg500元
2025/02/08HY-1010685-(十四烷基氧)-2-糠酸
TOFA
54857-86-210mM * 1mLin DMSO550元
"54857-86-2" 相關(guān)產(chǎn)品信息
220127-57-1 307002-71-7 115104-28-4 75747-14-7 211934-50-8 25414-22-6