54-71-7
54-71-7 結(jié)構(gòu)式
基本信息
鹽酸匹魯卡品(鹽酸毛果蕓香堿)
鹽酸毛果蕓香堿
匹魯卡品 鹽酸鹽
鹽酸匹魯卡品
鹽酸毛果蕓堿
毛果云香堿鹽酸鹽
(+)-毛果蕓香堿鹽酸鹽
(3S,4R)-4,5-二氫-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮鹽酸鹽
(+)-毛果蕓香堿鹽酸鹽,99%
(3S,4R)-4,5-DIHYDRO-3-ETHYL-4-(1-METHYL-1H-IMIDAZOL-5-YLMETHYL)-2(3H)-FURANONE HYDROCHLORIDE
(3S-CIS)-3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2(3H)-FURANONE HYDROCHLORIDE
ALMOCARPINE HYDROCHLORIDE
PILOCARPINE HCL
(+)-PILOCARPINE HYDROCHLORIDE
PILOCARPINE HYDROCHLORIDE
(3s-cis)-ochlorid
3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-,monohydrochloride,(3S-cis)-2(3H)-Furanone
3-ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanonmonohydr
almocarpine
ami-pilo
amisturap
isopto-carpine
mi-piloophthsol
pilocar
pilocarpine,monohydrochloride
pilocarpinemuriate
pilocel
pilomiotin
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
| Target | Value |
| mAChR |
Pilocarpine是一種擬副交感神經(jīng)生物堿，從美國熱帶灌木的毛果蕓香堿類植物的葉子中獲得。它是副交感神經(jīng)系統(tǒng)中非選擇性毒蕈堿型受體激動劑，其局部施用能夠有效作用于毒蕈堿型乙酰膽堿受體M3，例如青光眼和口干燥癥的治療。毛果蕓香堿作用于虹膜括約肌中毒蕈堿受體（M3）的一個(gè)亞型，引起肌肉收縮，瞳孔縮小。 Pilocarpine也作用于睫狀肌并使其收縮。當(dāng)睫狀肌收縮時(shí)，它通過增加鞏膜突的張力打開小梁網(wǎng)。這個(gè)動作促進(jìn)眼睛房水比率以降低眼內(nèi)壓。在眼科，毛果蕓香堿也可用于減少經(jīng)歷了人工晶狀體移植的患者夜晚對燈光產(chǎn)生眩光的可能性，pilocarpine會產(chǎn)生縮瞳作用，從而減輕這些癥狀。該用途最常用的濃度為1％pilocarpine，最低的濃度。Pilocarpine還能用于治療比如頭頸癌化療引起的口腔干燥癥。Pilocarpine會刺激大量唾液和汗液的分泌。
The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na + concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).