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37318-06-2

中文名稱 洋橄欖葉素
英文名稱 elaiophylin
CAS 37318-06-2
分子式 C54H88O18
分子量 1025.27
MOL 文件 37318-06-2.mol
更新日期 2024/12/31 09:16:45
37318-06-2 結(jié)構(gòu)式 37318-06-2 結(jié)構(gòu)式

基本信息

中文別名
洋橄欖葉素
英文別名
EfoMycin E
elaiophylin
GopalaMicin
EfoMycine E
Azalomycin B
255-E, 5001B, 56-62, 846 I, SNA 4606-3, AzaloMycin B, GopalaMicin, SalboMycin
所屬類別
分析化學:HPLC用溶劑

物理化學性質(zhì)

熔點179-182℃
沸點1080.5±65.0 °C(Predicted)
密度1.25
儲存條件-20°C冷凍
溶解度可溶于DMSO(少許)、甲醇(少許)
酸度系數(shù)(pKa)12.18±0.70(Predicted)
形態(tài)白色至類白色固體
顏色白色至灰白色

常見問題列表

概述
鹽霉素(Salinomycin)是由白色鏈霉菌經(jīng)發(fā)酵產(chǎn)生的聚醚類動物專用抗生素,具有防治動物球蟲病和促進畜禽生長發(fā)育的功能,被廣泛地用于國內(nèi)外的畜牧業(yè)中。但是,在鹽霉素產(chǎn)品中,如果發(fā)酵工藝或菌種發(fā)生變化,將會有洋橄欖葉素的伴生,當含量超出一定限度,將對飼養(yǎng)對象產(chǎn)生不良反應(yīng),一定程度上會影響鹽霉素的使用效果。
用途
洋橄欖葉素是一種微生物代謝物,可用作對照品。
生物活性
Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) 是一種自噬 (autophagy) 抑制劑,在卵巢癌細胞中作為單一藥劑發(fā)揮抗腫瘤活性。
靶點

Autophagy

體外研究

Elaiophylin-mediated autophagy inhibition and lysosomal dysfunction affect ovarian cancer cell survival during hypoxia. Exposure to Elaiophylin (0.025-0.5 μM; 24 hours) causes a significant increase in ovarian cancer SKOV3 cell death in hypoxia conditions.
In both the SKOV3 and A2780 cell lines, Elaiophylin (0.25, 0.5, 0.75 μM; 24 hours) treatment leads to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner.

Cell Viability Assay

Cell Line: Ovarian cancer SKOV3 cells.
Concentration: 0.025, 0.05, 0.1, 0.2, 0.5 μM
Incubation Time: 24 hours
Result: Caused a significant increase in ovarian cancer SKOV3 cells death in hypoxia conditions.

Western Blot Analysis

Cell Line: Ovarian cancer SKOV3 cells; A2780 cells
Concentration: 0.25, 0.5, 0.75 μM
Incubation Time: 24 hours
Result: Treatment led to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner.
體內(nèi)研究

Treatment with 2 mg/kg Elaiophylin (given i.p. every 2 days for 21 days; in BALB/C athymic mice) significantly suppresses ovarian cancer SKOV3 cells growth compared with DMSO treatment, resulting in a 72% decrease in the average daily tumor growth rate compared with DMSO treatment .
Lower doses of Elaiophylin as a single agent exert significant antitumor activity, while higher doses lead to intestinal toxicity. Administration of a lower dose (2 mg/kg) of Elaiophylin as a single agent achieves a significant antitumor effect without toxicity in an orthotopic ovarian cancer model with metastasis. Toxic reactions are observed only in the 8 mg/kg group.

Animal Model: 4-wk-old BALB/C athymic mice with ovarian cancer SKOV3 cells
Dosage: 1 or 2 mg/kg
Administration: Given i.p. every 2 days for 21 days
Result: Treatment with 2 mg/kg significantly suppressed ovarian cancer SKOV3 cells growth compared with DMSO treatment.
洋橄欖葉素價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-15184洋橄欖葉素
Elaiophylin
37318-06-21mg3920元
2024/08/19HY-15184洋橄欖葉素
Elaiophylin
37318-06-25mg9760元
2024/01/25HY-15184洋橄欖葉素
Elaiophylin
37318-06-210 mg5200元
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