36085-73-1
中文名稱
鹽酸他利克索
英文名稱
B-HT 920 DIHYDROCHLORIDE
CAS
36085-73-1
分子式
C10H17Cl2N3S
分子量
282.23
MOL 文件
36085-73-1.mol
更新日期
2024/10/22 00:23:13
36085-73-1 結(jié)構(gòu)式
基本信息
中文別名
鹽酸他利克索B-HT 920 二鹽酸鹽
英文別名
b-ht9204H-Thiazolo[4
B-HT 920 2HCl
5-d]azepin-2-aMine
hydrochloride (1:2)
Hydrochloric talipexole
B-HT 920 DIHYDROCHLORIDE
talipexole hydrochloride
B-HT 920 (hydrochloride)
talipexoledihydrochloride
所屬類別
有機(jī)原料：羧酸類化合物及衍生物安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302
防范說(shuō)明P280-P305+P351+P338
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22
WGK Germany3
RTECS號(hào)XJ7050340
常見問(wèn)題列表
生物活性
Talipexole dihydrochloride (B-HT 920 dihydrochloride) 是多巴胺D2受體和α2-腎上腺素受體激動(dòng)劑，5-HT3受體拮抗劑，有抗帕金森病活性。靶點(diǎn)
|
α2 25 nM (IC 50 ) |
D 2 Receptor
|
5-HT 3 Receptor
|
體內(nèi)研究
Intravenous injection of 30 micrograms/kg of Talipexole dihydrochloride (B-HT 920) into cats lead initially to an increase in blood pressure and then to a long-lasting decrease in blood pressure and heart rate. Vagally mediated reflex bradycardia elicited by angiotensin injection in beta-adrenoceptor-blocked dogs was facilitated by intracisternal injection of 10 micrograms/kg Talipexole dihydrochloride (B-HT 920).