328898-40-4
328898-40-4 結(jié)構(gòu)式
基本信息
泰地羅新溶液,100PPM
TILDIPIROSIN泰地羅新
泰地羅新 >95% BY HPLC
tildipirosin
Tildipirosin USP/EP/BP
TILDIPIROSIN 328898-40-4
TIP
TILDIPIROSIN
ZUPREVO.
Tildipirosin Solution, 100ppm
20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinylty
Tylonolide, 20-deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-β-D-glucopyranosyl]-20,23-di-1-piperidinyl-
20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinyltylonolide
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
泰地羅新具有特殊的三氮結(jié)構(gòu)，注射后吸收更迅速，細(xì)菌外壁穿透能力更強(qiáng)，與細(xì)菌核糖體蛋白結(jié)合位點(diǎn)更多，從而使其抑菌和殺菌的作用比一般的大環(huán)內(nèi)酯類抗生素更強(qiáng)。同時(shí)其特殊的三氮結(jié)構(gòu)可以延長(zhǎng)泰地羅新在肺組織和支氣管液中有效濃度時(shí)間。
泰地羅新是廣譜抗菌藥，對(duì)一些革蘭氏陽(yáng)性和革蘭氏陰性細(xì)菌均具有抗菌活性，對(duì)引起豬、牛呼吸系統(tǒng)疾病的病原菌尤其敏感，如胸膜肺炎放線桿菌、多殺性巴氏桿菌、支氣管敗血波氏桿菌、副豬嗜血桿菌以及溶血性曼海姆菌、睡眠嗜組織菌等。
Tildipirosin exhibits the inhibitory effect on C. coli species, and 23 of 31 (74%) isolates have MICs of 8 or 16 μg/mL while 8 of 31 (26%) have MIC >256 μg/mL. MICs against C. jejuni are 8-64 μg/mL. Tildipirosin against S. enterica and E. coli are 2-8 μg/mL. Tildipirosin inhibits the treponeme isolates form from CODD lesions from 19 sheep, with MIC90 of 0.0469 mg/L. The P. multocida B130 clones show the MIC of 0.25 mg/L for tildipirosin. The 10 P. multocida isolates that carry only erm(42) exhibit MIC of 16-32 mg/L for tildipirosin. The single M. haemolytica that harbours only erm(42) shows MIC of 32 mg/L for tildipirosin.
The mean percentage of lung consolidation for tildipirosin (4 mg/kg, s.c.)-treated calves is significantly lower than those for tulathromycin-treated and control calves. Metaphylactic administration of tildipirosin to calves 5 days prior to H somni challenge prevents subsequent culture of the pathogen from bronchial secretions and is more effective in minimizing clinical disease and lung lesions than is metaphylactic administration of tulathromycin.