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29376-68-9

中文名稱 黃花夾竹桃黃酮
英文名稱 Thevetiaflavone
CAS 29376-68-9
分子式 C16H12O5
分子量 284.26
MOL 文件 29376-68-9.mol
更新日期 2024/11/07 16:36:59
29376-68-9 結(jié)構(gòu)式 29376-68-9 結(jié)構(gòu)式

基本信息

中文別名
黃花夾竹桃黃酮
化合物 T13922
英文別名
Thevetiaflavone
5-O-METHYLAPIGENIN
Apigenin 5-methylether
Apigenin 5-O-monomethyl ether
4',7-Dihydroxy-5-methoxyflavone
Flavone,4',7-dihydroxy-5-methoxy- (8CI)
Apigenin-5-methyl ether,5-0-Methylapigenin
7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one
4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-
ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
所屬類別
天然產(chǎn)物:黃酮類化合物

物理化學(xué)性質(zhì)

熔點(diǎn)263℃
沸點(diǎn)567.9±50.0 °C(Predicted)
密度1.420
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)6.67±0.40(Predicted)
形態(tài)Solid
顏色Light yellow to yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335

常見問題列表

應(yīng)用
黃花夾竹桃黃酮抑制兔中性白細(xì)胞分泌β-葡萄糖醛酸酶,ED50為20μM;黃花夾竹桃黃酮抑制肌質(zhì)網(wǎng)狀組織Ca2+-ATPase,濃度為100μM時(shí),抑制率69%。
制備
從刺山柑中獲得精制提取物的方法,其特征在于,該方法包括以下步驟:a)使?jié)饪s的刺山柑粗提物上大孔吸附樹脂層析,依次用水和20-30%的乙醇溶液洗脫;b)再用50-100%的乙醇溶液洗脫,即得刺山柑精制提取物。所述總吲哚的主要化學(xué)成分為6-methoxybrassicanalA、6-methoxyspirobrassinin、3-醛基吲哚、3-醛基-4-羥基吲哚和Arvelexin。所述總黃酮的主要化學(xué)成分為槲皮素-3-蕓香糖苷、山奈酚-3-蕓香糖苷、黃花夾竹桃黃酮、金圣草素、櫻花素、銀杏黃素和異銀杏黃素。
生物活性
Thevetiaflavone 可以上調(diào) Bcl?2 的表達(dá),下調(diào) Bax 和 caspase-3 的表達(dá)。
靶點(diǎn)

Bcl-2

Bax

Caspase-3

體外研究

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.

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