285986-88-1
中文名稱
CCG1423
英文名稱
CCG-1423
CAS
285986-88-1
分子式
C18H13ClF6N2O3
分子量
454.751
MOL 文件
285986-88-1.mol
更新日期
2024/11/05 13:11:12
285986-88-1 結(jié)構(gòu)式
基本信息
中文別名
RHOA/C介導(dǎo)基因轉(zhuǎn)錄抑制劑(CCG-1423)N-[2-[(4-氯苯基)氨基]-1-甲基-2-氧代乙氧基]-3,5-二(三氟甲基)苯甲酰胺
N-({1-[(4-氯苯基)氨基]-1-氧代-2-丙基}氧基)-3,5-二(三氟甲基)苯甲酰胺
N-((1-((4-氯苯基)氨基)-1-氧代丙烷-2-基)氧基)-3,5-雙(三氟甲基)苯甲酰胺
英文別名
CCgCS-1769
CCG-1423
CCG1423, >98%
CCG 1423
CCG-1423
CCG-1423 USP/EP/BP
Rho/SRF Pathway Inhibitor, CCG-1423
Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem
N-[1-(4-chloroanilino)-1-oxopropan-2-yl]oxy-3,5-bis(trifluoromethyl)benzamide
N-(2-(4-Chloroanilino)-1-Methyl-2-oxoethoxy)-3,5-bis(trifluoroMethyl)benzaMide
所屬類別
生物化工：Rho 抑制劑物理化學(xué)性質(zhì)
儲存條件2-8°C
儲存條件Sealed in dry,Store in freezer, under -20°C
溶解度DMSO：可溶5mg/mL，澄清（加熱）
形態(tài)白色固體
顏色白色至米色
常見問題列表
生物活性
CCG-1423是一種特定的 RhoA 通路抑制劑，能夠抑制SRF介導(dǎo)的轉(zhuǎn)錄。體外研究
CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells. CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity. CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts.