22560-50-5
基本信息
氯屈膦酸鈉
氯屈膦酸二鈉
CLODRONATE DISODIUM
CLODRONIC ACID DISODIUM SALT
DICHLOROMETHYLENEDIPHOPHONIC ACID DISODIUM SALT
DICHLOROMETHYLENEDIPHOSPHONIC ACID DISODIUM SALT
DMDP
(dichloromethylene)bis-phosphonicacidisodiumsalt
(dichloromethylene)di-phosphonicacidisodiumsalt
bm06011
chlodronatesodium
clodronatesodium
dichloromethanediphosphonate
disodium(dichloromethylene)bisphosphonate
disodiumclodronate
lodronate
sodiumclodronate
disodium dihydrogen (dichloromethylene)diphosphonate
DICHLOROMETHYLENEDIPHOSPHONIC ACID
ClodronateAcidDisodiumSalt
Clodronate Disodium, Bonefos, Clasteon, Clastoban
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
Clodronate顯著降低J774細(xì)胞培養(yǎng)物的總存活率, EC50為300 μM,同時脂質(zhì)體包裹的Clodronate降低J774細(xì)胞培養(yǎng)物的總存活率,EC50為 1 μM。Clodronate 和脂質(zhì)體包裹的Clodronate代謝為一個不可水解的三磷酸腺苷(ATP)的類似物,腺苷5'-(β,γ-二氯亞甲基)三磷酸,它可以在J774細(xì)胞提取物中通過蛋白液相色譜進(jìn)行快速檢測。 Clodronate誘導(dǎo)離體的破骨細(xì)胞凋亡。Clodronate,當(dāng)在脂質(zhì)體中給藥時,也可誘導(dǎo)小鼠體外腹膜巨噬細(xì)胞和小鼠體內(nèi)肝巨噬細(xì)胞的凋亡,但對鼠巨噬細(xì)胞樣的RAW-264細(xì)胞沒有作用。 Clodronate被脂質(zhì)體輸送到巨噬細(xì)胞會殺死這些細(xì)胞作為細(xì)胞內(nèi)累積和不可逆代謝損傷的結(jié)果。依據(jù)治療方案,Clodronate包裹于脂質(zhì)體(clodrolip)作用于F9畸胎癌小鼠和攜帶人類A673橫紋肌肉瘤的小鼠模型,可有效地減少吞噬細(xì)胞從而顯著抑制75至> 92%的腫瘤的生長。 Clodronate,缺乏氮的二膦酸鹽,對蛋白質(zhì)異戊二烯化無抑制作用,但可以在細(xì)胞內(nèi)代謝為一種ATP類似物beta-gamma-methylene(AppCp型),這是對體外巨噬細(xì)胞的細(xì)胞毒作用。Clodronate代謝成AppCCl(2)p,然后AppCCl(2)P通過參與競爭性地抑制ADP / ATP移位酶的機(jī)制,從而抑制線粒體的氧消耗。
Clodronic acid (Clodronate) disodium salt (6.25-25 mg/kg; p.o.; daily for 28 days) slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg.
Animal Model: | Male Lewis rats, aged 7 weeks |
Dosage: | 6.25, 12.5, and 25 mg/kg |
Administration: | P.o.; daily for 28 days |
Result: | Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28. |
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/11 | XW225605051 | 氯磷酸二鈉 disodium clodronate;clodronic acid disodium salt;dichloromethylenediphosphonic acid disodium salt | 22560-50-5 | 200MG | 76元 |
2024/11/08 | HY-B0657A | 氯屈膦酸二鈉 Clodronic acid disodium salt | 22560-50-5 | 50mg | 185元 |
2024/11/08 | HY-B0657A | 氯屈膦酸二鈉 Clodronic acid disodium salt | 22560-50-5 | 10 mM * 1 mLin Water | 204元 |