217087-09-7
中文名稱
埃索美拉唑鎂(三水)
英文名稱
Esomeprazole magnesium trihydrate
CAS
217087-09-7
分子式
C34H42MgN6O9S2
MDL 編號
MFCD07698573
分子量
767.17
MOL 文件
217087-09-7.mol
更新日期
2025/01/13 16:40:11
217087-09-7 結構式
基本信息
中文別名
埃索美拉唑鎂(三水)二(5-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亞磺酰基]-1H-苯并咪唑-1-基)鎂鹽三水合物
英文別名
bis(5-methoxy-2-[(s)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1h-benzylimidazole-1-yl) magnesium trihydrateESOMEPRAZOLE MAGNESIUM
ESOMEPRAZOLE MAGNESIUM TRIHYDRATE
(T-4)-Bis[5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolato]magnesium
Nexium
ESOPMEPRAZOLE MG TRIHYDRATE
Bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzylimidazole-1-yl) magnesium trihydrate
ESOMEPRAZOLE MAGNESIUM TRIHYDRATE USP
物理化學性質
熔點184-189°C (dec.)
儲存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度微溶于水，溶于甲醇，幾乎不溶于庚烷。
形態(tài)neat
顏色White to off-white
InChIInChI=1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;
InChIKeyVEVZQDGATGBLIC-UHFFFAOYSA-N
SMILESC(C1N=CC(C)=C(OC)C=1C)S1C2[N-]C3=CC(OC)=CC=C3N=2[Mg+2]2(O=S(CC3N=CC(C)=C(OC)C=3C)C3[N-]C4=CC(OC)=CC=C4N2=3)O=1.O
常見問題列表
用途
奧美拉唑的S形式。胃質子泵抑制劑。
生物活性
Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一種有效的具有口服活性 H+, K+-ATPase 抑制劑，可用于上消化道疾病和胃食管反流疾病的研究。Esomeprazole magnesium trihydrate 是一種外泌體抑制劑，通過抑制 V-H+-ATPases 來阻斷外泌體的釋放。靶點
H + , K + -ATPase
體外研究
Esomeprazole magnesium trihydrate is develped from Esomeprazole strontium tetrahydrate (EST). EST contains esomeprazole, the S-enantiomer of omeprazole a salt-exchanged version of Esomeprazole magnesium trihydrate.
體內研究
Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity.
| Animal Model: | A/J mice |
| Dosage: | 0.5 mg/kg, 5 mg/kg, 50 mg/kg |
| Administration: | Oral gavage; daily; for 10 days |
| Result: | Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased. |