211096-49-0
中文名稱
化合物SB-265610
英文名稱
GSK-CXCR2
CAS
211096-49-0
分子式
C14H9BrN6O
分子量
357.16
MOL 文件
211096-49-0.mol
更新日期
2025/03/13 16:05:16
211096-49-0 結(jié)構(gòu)式
基本信息
中文別名
化合物SB-265610 英文別名
GSK-CXCR2SB 265610
SB265610 >=98% (HPLC)
N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-
1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea
CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
所屬類別
生物：拮抗劑物理化學(xué)性質(zhì)
沸點(diǎn)527.0±45.0 °C(Predicted)
密度1.77±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO：可溶15mg/mL，澄清
酸度系數(shù)(pKa)6.13±0.40(Predicted)
形態(tài)粉末
顏色白色至淺棕色
化合物SB-265610價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-50688 | 化合物SB-265610 SB-265610 | 211096-49-0 | 1 mg | 600元 |
| 2025/02/08 | HY-50688 | 化合物SB-265610 SB-265610 | 211096-49-0 | 10mM * 1mLin DMSO | 1179元 |
| 2025/02/08 | HY-50688 | 化合物SB-265610 SB-265610 | 211096-49-0 | 5 mg | 1500元 |
常見問題列表
生物活性
SB-265610 是一種選擇性的競爭性非肽變構(gòu) CXCR2 拮抗劑。SB-265610 阻斷大鼠 CINC-1 誘導(dǎo)的鈣動(dòng)員和中性粒細(xì)胞趨化性，IC50 分別為 3.7 nM 和 70 nM。靶點(diǎn)
|
CXCR2
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體外研究
In vitro, SB-265610 antagonizes rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization, IC 50 of 3.7 nM, and rat neutrophil chemotaxis in a concentration-dependent manner, IC 50 of 70 nM. SB-265610 reduces the antiapoptotic effect of CINC-1 to the levels of those untreated with CINC-1.
體內(nèi)研究
SB-265610 (100 mg/kg/day; oral administration; daily; for 5 days; CXCR2 wild type mice) treatment during the wound repair process markedly delays healing parameters in CXCR2 wild type mice.
| Animal Model: | Wild type mice with nitrogen mustard |
| Dosage: | 100 mg/kg/day |
| Administration: | Oral administration; daily; for 5 days |
| Result: | Markedly impaired the wound healing process. |