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20347-71-1

中文名稱 2-(3,4-二羥基苯基)-2-((2-(3,4-二羥基苯基)-5,7-二氫色滿-3-基)氧基)苯并二氫吡喃-3,4,5,7-四醇
英文名稱 2-(3,4-Dihydroxyphenyl)-2-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)chroman-3,4,5,7-tetraol
CAS 20347-71-1
分子式 C30H26O13
分子量 594.52
MOL 文件 20347-71-1.mol
更新日期 2025/01/07 18:54:25
20347-71-1 結(jié)構(gòu)式 20347-71-1 結(jié)構(gòu)式

基本信息

中文別名
2-(3,4-二羥基苯基)-2-((2-(3,4-二羥基苯基)-5,7-二氫色滿-3-基)氧基)苯并二氫吡喃-3,4,5,7-四醇
英文別名
Proanthocyanidins(b)
chroman-3,4,5,7-tetraol
-5,7-dihydroxychroman-3-yl)
-2-((2-(3,4-dihydroxyphenyl)
2H-1-Benzopyran-3,4,5,7-tetrol, 2-(3,4-dihydroxyphenyl)-2-[[2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl]oxy]-3,4-dihydro-

物理化學性質(zhì)

沸點986.4±65.0 °C(Predicted)
密度1.87±0.1 g/cm3(Predicted)
儲存條件Inert atmosphere,2-8°C
溶解度DMF: 3 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.5 mg/ml; PBS (pH 7.2): 10 mg/ml
酸度系數(shù)(pKa)9.24±0.70(Predicted)
形態(tài)固體
顏色Light brown to black

常見問題列表

生物活性
Proanthocyanidins 是一類在高等植物中廣泛分布的多酚化合物,由親電子黃烷?;鶈卧M成。Proanthocyanidins 可用作抗氧化劑和抗癌劑。Proanthocyanidins 還顯示出抗炎,保護心臟,抗菌和抗真菌的特性,可用于研究慢性靜脈功能不全、毛細血管脆弱、曬傷和視網(wǎng)膜病變。
體外研究

Proanthocyanidins are present in plants as complex mixtures of polymers. Predominant food sources are red wine, tea, chocolate and fruits like grapes, apples, pears, and cranberries.
The most interesting antibacterial activity of Proanthocyanidins is related to their presence in cranberries ( Vaccinium macrocarpon Ait.). A number of clinical trials have demonstrated the effectiveness of cranberry consumption in preventing urinary tract infections (UTIs). Although UTIs can be caused by many microorganisms, more than 85% are caused by Escherichia coli. The presence of P-fimbriae on E. coli , which are proteinaceous fibers on the bacterial cell wall, has been clearly established as a virulence factor, since they are responsible by producing adhesions for adherence to uroepithelial cells. Recently, it is demonstrated that cranberry Proanthocyanidins might inhibit P-fimbriated E. coli from adhering to uroepithelial cells. The antiadhesion activity of cranberry juice appears to be related to the presence of Proanthocyanidins with at least one A-type linkage.

體內(nèi)研究

The effects of cacao liquor Proanthocyanidins on 2- amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced mutagenesis in vivo carcinogenesis in female Sprague-Dawley rats are investigated. In the Ames assay, Proanthocyanidins shows strong antimutagenic effects when assayed in the presence of S-9 mixture. They also inhibit significantly rat pancreatic carcinogenesis in the initiation stage, but not mammary carcinogenesis.

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