17560-51-9
基本信息
美托拉宗
美托拉腙
甲醋唑胺
DIULO
METENIX
METOLAZONE
MYKROX
OLDREN
SR-720-22
1,2,3,4-tetrahydro-7-chloro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid
2-methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
6-quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylpheny
6-quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-toly
7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolines
7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesul
7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid
7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-tolyl-6-quinazolinesulfonamide
fonamide
l)-4-oxo-
metalozone
microx
s720-22
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-B0209 | 美托拉宗 Metolazone | 17560-51-9 | 50mg | 600元 |
2024/11/08 | HY-B0209 | 美托拉宗 Metolazone | 17560-51-9 | 10mM * 1mLin DMSO | 660元 |
2024/11/08 | S1610 | 美托拉宗 Metolazone | 17560-51-9 | 50mg | 812.06元 |
常見問題列表
Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.