17388-39-5
中文名稱
獐牙菜苦甙
英文名稱
Swertiamarine
CAS
17388-39-5
分子式
C16H22O10
MDL 編號(hào)
MFCD07783984
分子量
374.34
MOL 文件
17388-39-5.mol
更新日期
2025/01/07 18:51:24
17388-39-5 結(jié)構(gòu)式
基本信息
中文別名
5-乙烯基-6-(β-D-吡喃葡糖氧基)-4,4α,5,6-四氫-4α-羥基-1H,3H-吡喃并[3,4-C]吡喃-1-酮獐牙菜苦苷
獐牙菜苦甙
獐牙菜苦素
5-乙烯基-6-(beta-D-吡喃葡糖氧基)-4,4a,5,6-四氫-4a-羥基-1H,3H-吡喃并[3,4-C]吡喃-1-酮
當(dāng)藥苦苷
英文別名
SWERTIAMAINSWERTIAMARIN
(4ar-(4a-alpha,5-beta,6-alpha))-ranosyloxy)-4a-hydroxy
1h,3h-pyrano(3,4-c)pyran-1-one,4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopy
1H,3H-Pyrano[3,4-c]pyran-1-one,4,4.alpha.,5,6-tetrahydro-5-ethenyl-6-(.beta.-D-glucopyranosyloxy)-4.alpha.-hydroxy-,[4ar-(4.alpha.-.alpha.,5-.beta.,D-.alpha.)]-
3H-Pyrano[3,4-c]pyran-1-one,4,4.alpha.,5,6-tetrahydro-5-ethenyl-6-(.beta.-D-glucopyranosyloxy)-4.1H
4-c)pyran-1-one,4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopyranosyloxy)-4a-hydroxy-3h-pyrano(1
Swertiamarin(6CI,7CI,8CI)
Swertiamarine
Swertiamaroside
SWERTIAMARIN, 98+% BY HPLC
Swertiamarin std.
SWERTIAMARIN(P)
(5R,6S)-5-Ethenyl-4a-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,5,6-tetrahydropyrano[5,4-c]pyran-1-one
glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-,(4aR,5R, 6S)-
Swertiamarin，Swertiamarine，Swertiamaroside
(4aR)-4aα-Hydroxy-5β-vinyl-6α-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one
4aα-Hydroxy-6α-(β-D-glucopyranosyloxy)-5β-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one
6α-(β-D-Glucopyranosyloxy)-4,4a,5,6-tetrahydro-4aα-hydroxy-5β-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one
所屬類別
原料藥：胃腸解痙藥物理化學(xué)性質(zhì)
外觀性質(zhì)屬裂環(huán)環(huán)烯醚萜苷類化合物。無(wú)色粉末，味苦。在空氣中略有吸濕性。易溶于甲醇、乙醇、微溶于水，不溶于氯仿、石油醚。熔點(diǎn)：113～115℃
外觀性狀白色結(jié)晶體，易溶于水、甲醇、乙醇，幾乎不溶于氯仿、乙醚，石油醚，來(lái)源于長(zhǎng)梗秦艽（西藏）當(dāng)藥、獐牙菜、青葉膽，魚(yú)腥草。
熔點(diǎn)113-114°
比旋光度D20 -127° (c = 1 in 96% ethanol)
沸點(diǎn)649.3±55.0 °C(Predicted)
密度1.57±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C
溶解度DMSO : 250 mg/mL (667.84 mM; Need ultrasonic)
酸度系數(shù)(pKa)11.56±0.60(Predicted)
形態(tài)neat
顏色白色到黃色到橙色
最大波長(zhǎng)(λmax)238nm(MeOH)(lit.)
Merck14,9010
BRN55278
穩(wěn)定性Hygroscopic
InChIKeyHEYZWPRKKUGDCR-QBXMEVCASA-N
CAS 數(shù)據(jù)庫(kù)17388-39-5(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301-H314-H317-H351-H410
安全說(shuō)明24/25
WGK Germany3
RTECS號(hào)UQ1366700
海關(guān)編碼29389090
毒性mouse,LD50,intraperitoneal,> 8gm/kg (8000mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 464, 1982.
常見(jiàn)問(wèn)題列表
概述
獐牙菜苦甙系從龍膽科植物斜莖獐牙菜中分離而得的一種環(huán)烯醚萜類化合物。在對(duì)大鼠的活體實(shí)驗(yàn)中，發(fā)現(xiàn)獐牙菜苦甙可以減少毒性物質(zhì)對(duì)肝的傷害，還可預(yù)防大鼠由缺氧引起的肝損傷。